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IL6 — PTPRC

Text-mined interactions from Literome

Ishikawa et al., Leukemia & lymphoma 2000 (Multiple Myeloma) : IL-6 can also induce expression of CD45 on the MPC-1- CD45- subpopulation of immature myeloma cells ... In the U266 cell line, IL-6 leads to the induction of CD45 expression and cell proliferation, indicating that IL-6 induced effects are closely linked to CD45 expression
Gao et al., Exp Hematol 2000 : FcgammaRIIa cross linking resulted in significantly increased concentrations of secreted IL-6 compared to untreated neutrophils, and IL-6 production was further enhanced by cocross linking CD45 with FcgammaRIIa ... Cross linking CD45 alone also induced IL-6 production
Kawano et al., Int J Hematol 2002 (MAP Kinase Signaling System...) : In the U-266 cell lines, IL-6 can lead to the induction of CD45 expression and CD45+ U-266 cells can proliferate in response to IL-6
Zhou et al., Int J Hematol 2004 (Multiple Myeloma) : The protein tyrosine phosphatase CD45 is required for interleukin 6 signaling in U266 myeloma cells ... An association between CD45 and the Src-family protein tyrosine kinase, Lyn, was maintained in the presence of IL-6 ; the formation of the CD45/Lyn complex was impaired by vanadate
Li et al., Blood 2005 (Multiple Myeloma) : Here, we showed that IL-6 induced the translocation of CD45 to lipid rafts in an isoform dependent manner
Piercy et al., Immunology 2006 : CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells
Collette et al., Eur Cytokine Netw 2007 (Multiple Myeloma) : Using a pharmacological Erk inhibitor, we show that the Erk/MAPK pathway is involved in IL-6 induced clonogenicity of CD45+, but not CD45- myeloma cell lines
Corvaïa et al., Eur J Immunol 1995 : In contrast to calcium mobilization and tyrosine phosphorylation of proteins, IL-6 production was not affected by co-cross linking of CD45 with either Fc gamma RI or Fc gamma RII ... Interestingly, cross linking of the CD45 itself was sufficient to induce IL-6 production
Mahmoud et al., Blood 1998 (Multiple Myeloma) : Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6 ... Moreover, we showed that IL-6 stimulation led to the induction of expression of CD45 and cellular proliferation ... Our data show that the expression pattern of CD45 in myeloma cell lines is heterogeneous and show for the first time that CD45 expression can be induced by IL-6 stimulation