Schmidt et al., Int J Immunopharmacol 1990
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These results suggest that c3Ado is a selective inhibitor of RNA synthesis and inhibits IL-1 production and activity by blocking new messenger RNA production induced by LPS or IL-1
Parmely et al., J Immunol 1993
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In this study ADO and the synthetic ADO analogue MDL201112 inhibited TNF-alpha, but not IL-1 , production by activated mouse peritoneal macrophages and the macrophage-like cell lines J774 and RAW-264