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AHSA1 — IL1A
Text-mined interactions from Literome
Sheng et al., Neurochem Int 2001
(Alzheimer Disease) :
This, together with findings showing that IL-1 activates MAPK-p38 in vitro and is markedly overexpressed in Alzheimer brain, suggest a role for
IL-1 induced
MAPK-p38 activation in the genesis of neurofibrillary pathology in Alzheimer 's disease
Thomas et al., Biochem J 2002
:
Interestingly,
IL-1beta induced
p38 MAPK activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells
Vela et al., Mol Cell Neurosci 2002
:
Regarding intracellular signaling,
IL-1beta activated the
p38 mitogen activated protein kinase ( MAPK ) but not the p42/p44 MAPK and, when combined with growth factors, intensified p38 activation but inhibited the growth-factor induced p42/p44 activation
Kim et al., Mol Pharmacol 2002
:
These results indicate that in human pulmonary epithelial cells,
IL-1beta activates ERK or
p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production
Lee et al., J Biomed Sci 2003
(Liver Cirrhosis) :
Differential
role of
p38 in
IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line
Huang et al., Nat Immunol 2004
:
Furthermore, MEKK3 is crucial for
IL-1- and LPS induced
activation of NF-kappaB and
JNK-p38 but not ERK, indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Kim et al., J Neurochem 2004
:
IL-1 or IL-1/IFNbeta induced RANTES/CCL5 expression was
inhibited by the super-repressor IkappaBalpha or inhibitors of
p38 or c-Jun N-terminal kinase (JNK) MAPKs ( mitogen activated protein kinases ), but not by extracellular signal regulated kinases ( ERK ) inhibitors
Farivar et al., J Heart Lung Transplant 2004
(Bronchiolitis Obliterans...) :
p38 regulates the expression of the cytokines tumor necrosis ( TNF)-alpha and
interleukin (IL)-1beta , 2 mediators involved in the development of OB in a tracheal transplant model
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005
:
Consistently,
IL-1beta stimulated phosphorylation of p42/p44 MAPK,
p38 , and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively
Størling et al., Diabetologia 2005
:
Likewise,
IL-1beta induced JNK and
p38 activities were lower in iNOS ( -/- ) mouse islets than in wild-type islets
Zhang et al., Molecular vision 2009
:
Furthermore, BOL-303242-X inhibited
IL-1ss induced decreases in IkappaB-alpha levels, as well as IL-1ss induced phosphorylation of NFkappaB,
p38 , and c-Jun-N-terminal kinase (JNK) MAPKs in HCEpiCs
Tanabe et al., Journal of neuroinflammation 2011
:
We previously reported that interleukin (IL)-1ß stimulates IL-6 synthesis from rat C6 glioma cells and that
IL-1ß induces phosphorylation of inhibitory kappa B ( I?B ),
p38 mitogen activated protein ( MAP ) kinase, stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase 1/2, and signal transducer and activator of transcription ( STAT ) 3
Turner-Brannen et al., Arthritis Res Ther 2011
(Inflammation) :
With various immunochemical assays, it was further demonstrated that
IL-1ß induced NF-?B, JNK, and
p38 mitogen activated protein kinase ( MAPK ) activations were significantly suppressed by IDR-1002
Huang et al., J Neurosci 2011
:
In astrocytes, IL-1ß induced both the p38 MAPK and NF-?B ( nuclear factor ?B ) pathways regulating inflammatory responses, however in hippocampal neurons
IL-1ß activated
p38 but not NF-?B
Drube et al., Eur J Pharmacol 2012
:
Treatment of HMC-cells with the c-Kit inhibitor STI571 blocked the
IL-1ß induced activation of Erk1/2 and JNK1/2 but not
p38 and NF?B
Akhtar et al., Ann Rheum Dis 2012
(Osteoarthritis) :
IL-1ß induced activation of
p38-MAPK correlates inversely with miR199a* expression levels
Jagielska et al., Arterioscler Thromb Vasc Biol 2012
(Disease Models, Animal...) :
Accordingly, cellular cholesterol depletion ( cyclodextrin ) and silencing of caveolin-1 ( small interfering RNA ) inhibited
IL-1ß induced activation of
p38-MAPK and MK2, as well as IL-1ß induced tube formation and migration
Simões et al., Journal of neuroinflammation 2012
(MAP Kinase Signaling System) :
The effect of SCH58261 on the
IL-1ß induced phosphorylation of the mitogen activated protein kinases ( MAPKs ) c-Jun N-terminal kinase (JNK) and
p38 was evaluated by western blotting and immunocytochemistry ...
IL-1ß ( 10 to 100 ng/ml )
enhanced both JNK and
p38 phosphorylation, and these effects were prevented by the IL-1 type 1 receptor antagonist IL-1Ra ( 5 µg/ml ), in accordance with the neuronal localization of IL-1 type 1 receptors, including pre-synaptically and post-synaptically
Howard et al., Shock 2013
(Acute Lung Injury...) :
Further analysis demonstrates prolonged preservation of aENaC expression by the activation of the heat shock response that involves inducible Hsp70. Inhibition of Hsp70 at 24 h after heat shock results in
p38 dependent
IL-1ß inhibition of aENaC mRNA expression, whereas overexpression of Hsp70 attenuates the p38 dependent IL-1ß inhibition of aENaC mRNA expression