Gene interactions and pathways from curated databases and text-mining

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CCL5 — IL1A

Text-mined interactions from Literome

Kim et al., J Neurochem 2004 : Ribonuclease protection assay and ELISA showed that IFNbeta, although not effective alone, increased IL-1 induced RANTES/CCL5 expression, but did not antagonize IFNgamma ... IL-1 or IL-1/IFNbeta induced RANTES/CCL5 expression was inhibited by the super-repressor IkappaBalpha or inhibitors of p38 or c-Jun N-terminal kinase (JNK) MAPKs ( mitogen activated protein kinases ), but not by extracellular signal regulated kinases ( ERK ) inhibitors ... Transfection with mutated RANTES/CCL5 promoter-reporter constructs revealed that kappaB, interferon stimulated response element ( ISRE ) and CAATT-enhancer binding protein-beta ( C/EBPbeta ) sites all contributed to IL-1/IFNbeta induced RANTES/CCL5 transcription
Wolf et al., PloS one 2011 : It also enhances TAB1 dependent CCL5 secretion in response to IL-1 and increases activity of a post-transcriptional reporter gene, which contains the CCL5 3 ' untranslated region
Alexander et al., Physiol Genomics 2012 (Inflammation...) : Finally, immunofluorescent staining of mouse atherosclerotic lesions revealed the presence of cells positive for the marker of an IL-1ß stimulated inflammatory SMC, chemokine (C-C motif) ligand 20 ( CCL20 ), but not the PDGF-DD induced gene, regulator of G protein signaling 17 ( RGS17 )