Gene interactions and pathways from curated databases and text-mining

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IL1A — SOD2

Text-mined interactions from Literome

Maehara et al., J Cell Biochem 2000 : Expression of the manganese superoxide dismutase ( Mn-SOD ) is induced by tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) , and lipopolysaccharide (LPS)
Strålin et al., Atherosclerosis 2000 : The Mn-SOD activity was strongly up-regulated by TNF-alpha and IL-1alpha and moderately by IFN-gamma
Ono et al., Biochem Biophys Res Commun 1992 (Carcinoma, Hepatocellular...) : Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1) , Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
Marklund et al., J Biol Chem 1992 : TNF-alpha, IL-1 alpha, and IFN-gamma stimulated the Mn-SOD activity, as previously known, and these responses were reduced by TGF-beta
Tsan et al., Am J Physiol 1992 (Anoxia) : However, IL-6 markedly enhances TNF-alpha- and IL-1 induced increases in Mn SOD mRNA levels and O2 tolerance
Kim et al., Arthritis Res Ther 2006 (Osteoarthritis) : Effects of transduced Tat-SOD on the regulation of IL-1 induced nitric oxide ( NO ) production and inducible nitric oxide synthase (iNOS) mRNA expression was assessed by the Griess reaction and reverse transcriptase PCR, respectively
Mathy-Hartert et al., Osteoarthritis Cartilage 2008 : In parallel, IL-1beta markedly enhanced Mn SOD and GPX gene expressions, but decreased Cu/Zn SOD, EC SOD and CAT gene expressions
DiSilvestro et al., Proc Soc Exp Biol Med 1991 : In contrast, our study found that interleukin 1 (IL-1) can increase Cu-Zn SOD activities in human W138 lung fibroblasts ... On the other hand, some other potential experimental variables showed little or no effects on IL-1 induced increases in Cu-Zn SOD activities
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012 (Acute Lung Injury) : Compared with those in LPS group, IL-1ß , IL-6, TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and SOD in the BALF significantly increased in LPS+DAS group
Kong et al., Lipids in health and disease 2013 : However, comparing to the model rabbits, levels of TNF-a, IL-1ß and MDA decreased significantly and serum SOD activity increased , gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
Masuda et al., FASEB J 1988 : However, IL 1 also induced Mn SOD in normal human skin fibroblasts and peripheral blood mononuclear cells, whose growth was stimulated by IL 1 ... The results show that induction of Mn SOD by IL 1 is a common biochemical event in IL 1-responsive cells
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : TNF alpha and IL-1 each can activate NF-kappa B and induce gene expression of manganese superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Nakata et al., Int J Cancer 1993 : These data suggest that, in vivo, the TNF alpha and IL-1 alpha produced by cancer cells and other cells may induce Mn-SOD in vascular endothelial cells as well as other host tissues, resulting in release of a relatively large amount of this protein into the serum
Hirose et al., FASEB J 1993 (Melanoma) : Interleukin-1 (IL-1) and tumor necrosis factor (TNF) selectively induce mitochondrial manganese superoxide dismutase ( MnSOD ) production in various cell types
Nogae et al., J Mol Cell Cardiol 1995 (Arrhythmias, Cardiac...) : Interleukin 1 alpha induced expression of manganous superoxide dismutase reduces myocardial reperfusion injury in the rat
Melendez et al., J Biol Chem 1996 (Fibrosarcoma) : Of the TNF induced transcripts analyzed, only interleukin-1alpha (IL-1alpha) was modulated in response to Mn-SOD overexpression ... The effect of Mn-SOD overexpression on IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate
Sasaki et al., Photochem Photobiol 1997 : Interleukin-1 alpha and TNF-alpha enhanced both the SOD activity and protein level of Mn SOD , while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h
Derevianko et al., Shock 1998 : IL-1betaR type I expression was significantly up-regulated in the presence of catalase and SOD