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IL1A — SOD2
Text-mined interactions from Literome
Maehara et al., J Cell Biochem 2000
:
Expression of the manganese superoxide dismutase (
Mn-SOD ) is
induced by tumor necrosis factor-alpha (TNF-alpha),
interleukin-1 (IL-1) , and lipopolysaccharide (LPS)
Strålin et al., Atherosclerosis 2000
:
The
Mn-SOD activity was strongly
up-regulated by TNF-alpha and
IL-1alpha and moderately by IFN-gamma
Ono et al., Biochem Biophys Res Commun 1992
(Carcinoma, Hepatocellular...) :
Effects of Tumor Necrosis Factor (TNF),
Interleukin-1 (IL-1) , Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of
Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
Marklund et al., J Biol Chem 1992
:
TNF-alpha,
IL-1 alpha, and IFN-gamma
stimulated the
Mn-SOD activity, as previously known, and these responses were reduced by TGF-beta
Tsan et al., Am J Physiol 1992
(Anoxia) :
However, IL-6 markedly enhances TNF-alpha- and
IL-1 induced increases in Mn
SOD mRNA levels and O2 tolerance
Kim et al., Arthritis Res Ther 2006
(Osteoarthritis) :
Effects of transduced
Tat-SOD on the regulation of
IL-1 induced nitric oxide ( NO ) production and inducible nitric oxide synthase (iNOS) mRNA expression was assessed by the Griess reaction and reverse transcriptase PCR, respectively
Mathy-Hartert et al., Osteoarthritis Cartilage 2008
:
In parallel,
IL-1beta markedly
enhanced Mn
SOD and GPX gene expressions, but decreased Cu/Zn SOD, EC SOD and CAT gene expressions
DiSilvestro et al., Proc Soc Exp Biol Med 1991
:
In contrast, our study found that
interleukin 1 (IL-1) can
increase Cu-Zn
SOD activities in human W138 lung fibroblasts ... On the other hand, some other potential experimental variables showed little or no effects on
IL-1 induced increases in Cu-Zn
SOD activities
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012
(Acute Lung Injury) :
Compared with those in LPS group,
IL-1ß , IL-6, TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and
SOD in the BALF significantly
increased in LPS+DAS group
Kong et al., Lipids in health and disease 2013
:
However, comparing to the model rabbits, levels of TNF-a,
IL-1ß and MDA decreased significantly and serum
SOD activity
increased , gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
Masuda et al., FASEB J 1988
:
However, IL 1 also
induced Mn
SOD in normal human skin fibroblasts and peripheral blood mononuclear cells, whose growth was stimulated by
IL 1 ... The results show that
induction of Mn
SOD by
IL 1 is a common biochemical event in IL 1-responsive cells
Das et al., Mol Cell Biochem 1995
(Adenocarcinoma...) :
TNF alpha and
IL-1 each can activate NF-kappa B and
induce gene expression of manganese
superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Nakata et al., Int J Cancer 1993
:
These data suggest that, in vivo, the TNF alpha and
IL-1 alpha produced by cancer cells and other cells may
induce Mn-SOD in vascular endothelial cells as well as other host tissues, resulting in release of a relatively large amount of this protein into the serum
Hirose et al., FASEB J 1993
(Melanoma) :
Interleukin-1 (IL-1) and tumor necrosis factor (TNF) selectively
induce mitochondrial manganese
superoxide dismutase ( MnSOD ) production in various cell types
Nogae et al., J Mol Cell Cardiol 1995
(Arrhythmias, Cardiac...) :
Interleukin 1 alpha induced expression of manganous
superoxide dismutase reduces myocardial reperfusion injury in the rat
Melendez et al., J Biol Chem 1996
(Fibrosarcoma) :
Of the TNF induced transcripts analyzed, only
interleukin-1alpha (IL-1alpha) was modulated in
response to
Mn-SOD overexpression ... The
effect of
Mn-SOD overexpression on
IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate
Sasaki et al., Photochem Photobiol 1997
:
Interleukin-1 alpha and TNF-alpha
enhanced both the SOD activity and protein level of Mn
SOD , while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h
Derevianko et al., Shock 1998
:
IL-1betaR type I expression was significantly up-regulated in the
presence of catalase and
SOD