Gene interactions and pathways from curated databases and text-mining

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PAK1 — PAK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Volinsky et al., Biochem J 2006 : Pak(i) potently inhibited SDF-1alpha induced Pak activation by a bivalent mechanism, as indicated by its complete inactivation upon point mutation of two binding sites, but partial inactivation upon mutation of either site alone
Nukada et al., Int Immunol 2006 : PAK3 is induced by the activation of T cells, whereas PAK1 is constitutively expressed in both naive and activated T cells
Combeau et al., J Biol Chem 2012 (Genetic Diseases, X-Linked...) : Using kinase assays, we demonstrate that PAK1 inhibits the activity of PAK3a but not of the splice variant PAK3b in a trans-regulatory manner
Rouquette-Jazdanian et al., Mol Cell 2012 (MAP Kinase Signaling System) : The PLC-?1 ( SH3 ) -Pak1 interaction activates Pak1 independently of the small GTPases Rac1/Cdc42, previously described as being the only activators of Pak1 in T cells
Bokoch et al., J Biol Chem 1998 : Lipid stimulation of PAK1 activity was dependent upon intact PAK kinase activity, as indicated by studies with a kinase-dead PAK1 mutant