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EPHB2 — TLR2

Text-mined interactions from Literome

An et al., Immunology 2002 : Involvement of ERK , p38 and NF-kappaB signal transduction in regulation of TLR2 , TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
Goral et al., J Immunol 2005 (Inflammation) : Acute ethanol treatment inhibited IL-6 and TNF-alpha synthesis and impaired p38 and ERK1/2 activation induced by TLR2 , TLR4, and TLR9 ligands
Miller et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis) : In turn, TLR4 regulated phosphorylation of ERK1/2 but not of Akt, suggesting that mmLDL induced PI3K activation is TLR4 independent
Banerjee et al., Proc Natl Acad Sci U S A 2006 : Despite rescuing TLR dependent ERK activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase, c-Raf ( Raf : ER ), CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER, a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms
Dubourdeau et al., J Immunol 2006 (MAP Kinase Signaling System) : Our investigations revealed that immunocompetent TLR2, TLR4 , and MyD88 knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs ERK and p38 was not affected in TLR2, TLR4, or MyD88 knockout mice following stimulation with conidia
Toshchakov et al., J Immunol 2007 (MAP Kinase Signaling System) : TLR4- and TLR2-BBPs also strongly inhibited LPS induced activation of ERK ... Only TLR2-BBP significantly inhibited ERK activation induced by P3C, which acts via TLR2/1 heterodimers ... The TLR2-BBP induced weak activation of p38, but not ERK or cytokine mRNA
Kawakami et al., J Rheumatol 2007 (Sjogren's Syndrome) : TLR ligands induced phosphorylation of ERK , JNK, and p38 in HSG cells, but not Akt phosphorylation or activation of NF-kappaB p65
Loniewski et al., Mol Immunol 2007 : In contrast to TLR4 signaling, TLR7 activation of ERK , JNK pathways and phosphorylation of p105 and I kappa B alpha are completely inhibited in TRAF6 knockdown cells ... These results suggest that while TRAF6 is absolutely essential for TLR7 activation of ERK, JNK and NF kappa B pathways, TLR4 induced ERK , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6
Lagoumintzis et al., Scand J Immunol 2008 (Pseudomonas Infections) : Activation of both p38 and ERK1/2 induced by P. aeruginosa slime-GLP was dramatically reduced in the presence of anti-TLR2 and to a lesser degree in the presence of anti-TLR4, whereas the P. aeruginosa-LPS induced stimulation was inhibited only in the presence of anti-TLR4
MacLeod et al., Clinical and vaccine immunology : CVI 2008 : PorB was able to induce ( i ) protein tyrosine kinase ( PTK ) activity, ( ii ) the phosphorylation of Erk1 and Erk2, and ( iii ) IkappaB-alpha phosphorylation, leading to NF-kappaB nuclear translocation in B cells in a TLR2 dependent manner
West et al., Immunology 2008 (Vasculitis) : ISO-1 is a promising parent molecule which inhibits TLR induced ERK activation and inflammatory cytokine production in monocytes, whose role may be complicated by cell-type specificity
Chandra et al., Clin Exp Immunol 2008 (Leishmaniasis, Visceral...) : Parasites also modulated the TLR2 stimulated mitogen activated protein kinase ( MAPK ) pathway by suppressing MAPK P(38) phosphorylation and activating extracellular regulated kinase (ERK)1/2 phosphorylation
Mkaddem et al., J Biol Chem 2009 (Kidney Diseases...) : Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2) mediated activation of extracellular signal regulated kinase ( ERK ) 1/2 in post-hypoxic kidney cells ... Inhibition of PP5 by okadaic acid, and Pp5 siRNA also restored TLR2 mediated phosphorylation of ERK1/2 , and apoptosis signal regulating kinase 1 ( ASK1 ) /c-Jun N-terminal kinase (JNK) mediated apoptosis in post-hypoxic Tlr2-deficient RTECs ... These findings indicate that gp96 interacts with PP5 and controls TLR2 mediated induction of ERK1/2 in post-hypoxic renal tubule cells
Chiu et al., Chem Biol Interact 2009 : Propofol inhibits lipoteichoic acid induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB
Chang et al., Shock 2010 : Thus, this study shows that one possible mechanism involved in ketamine induced inhibition of LTA induced TNF-alpha and IL-6 gene expressions and oxidative stress production is through downregulating TLR2 mediated phosphorylation of ERK1/2 and the subsequent translocation and transactivation of NFkappaB
Kaji et al., J Immunol 2010 : Bacterial teichoic acids reverse predominant IL-12 production induced by certain lactobacillus strains into predominant IL-10 production via TLR2 dependent ERK activation in macrophages ... The effect of these teichoic acids on IL-10 production was mediated by TLR2 dependent ERK activation
Ben Mkaddem et al., Chang Gung Med J 2010 (Bacterial Infections...) : The activation of the mitogen associated protein kinase ERK1/2 in post-hypoxic RTECs has also been shown to be selectively regulated by TLR2 via the serine-threonine protein phosphatase 5, which is associated with the endoplasmic reticulum resident heat shock protein, gp96, which acts as a master chaperone of TLRs
Park et al., Oncogene 2011 (Adenocarcinoma...) : In agreement with the result of TLR2 mediated ERK activation by PAUF, PAUF induces increased expression of the protumorigenic cytokines RANTES and MIF in THP-1 cells ... Together, these findings suggest that the new cancer associated ligand, PAUF, may activate TLR mediated ERK signaling to produce the protumorigenic cytokines, but inhibits TLR mediated NF-?B signaling, thereby facilitating tumor growth and escape from innate immune surveillance
Mkaddem et al., Oncotarget 2010 (Anoxia...) : Here, we summarise recent findings concerning the role of the protein phosphatase 5 involved in the selective regulation of TLR2 mediated ERK1/2 signaling and the identification of the key role of the non-phagocytic NADPH oxidase 4 producing reactive oxygen species in the control of TLR4 mediated apoptosis in murine models of renal I/R injury and in post-hypoxic kidney tubule cells
Paulino et al., J Neurovirol 2011 (Coinfection...) : Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
Zhang et al., Cell Mol Immunol 2012 : Furthermore, Ras-guanine nucleotide releasing protein 1 ( RasGRP1 ) mediated the TLR2 induced ERK1/2 activation and inhibition of IL-12p40 production
Mohammad et al., Exp Eye Res 2013 (Diabetes Mellitus, Experimental...) : Diabetes induced significant upregulation of the expression of HMGB-1, receptor for advanced glycation end products ( RAGE ), ERK ( 1/2 ) and nuclear transcription factor Kappa B ( NF-?B ), whereas the expression of toll-like receptor 2 (TLR2) and occludin was significantly downregulated
Zhang et al., PloS one 2013 (MAP Kinase Signaling System) : YCP interaction with TLR2 and TLR4 led to the activation of intracellular p38, ERK and JNK, as well as the translocation of transcriptional factor NF-?B into nucleus