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CALM3 — IL8

Text-mined interactions from Literome

Abe et al., Am J Respir Cell Mol Biol 2000 : In the present study we investigated the effects of clarithromycin (CAM) on interleukin (IL)-8 gene expression and protein levels, using the human bronchial epithelial cell line BET-1A ... Northern blot analyses showed that CAM inhibited tumor necrosis factor (TNF)-alpha induced IL-8 gene expression in a dose- and incubation time dependent manner
Fujita et al., Eur Arch Otorhinolaryngol 2000 (Chronic Disease...) : In vitro effects of EM and CAM on IL-8 secretion were examined in nasal epithelial cells cultured at the air-liquid interface
Nozawa et al., Biochem Pharmacol 2002 : Calmodulin inhibitors ( W7 and calmidazolium ) and tyrosine kinase inhibitors ( genistein and ST638 ) completely blocked IL-8 release by H. pylori and A23187 ... H. pylori induced IL-8 production is dominantly regulated by Ca2+/calmodulin signaling, and ERK plays an important role in signal transmission for the efficient activation of H. pylori induced NF-kappaB activity, resulting in IL-8 production
Zeng et al., Acta Pharmacol Sin 2005 : Inhibitors of PKC ( calphostin C, 50-500 nmol/L and RO-31-8220, 10-100 nmol/L ), CaM ( W7, 28-280 micromol/L ), ERK1/2 MAPK ( PD 98059, 2-20 micromol/L ), p38 MAPK ( SB 203580, 0.6-6 micromol/L ), JNK MAPK ( curcumin, 2-10 micromol/L ), and NF-kappaB ( PDTC, 10-100 nmol/L ) markedly reduced Hcy 100 micromol/L induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK ( genistein, 2.6-26 micromol/L and tyrphostin, 0.5-5 micromol/L ) had no obvious effect on MCP-1 and IL-8 production
Shinkai et al., Am J Physiol Lung Cell Mol Physiol 2006 : AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony stimulating factor at 48 h ... In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 ( P < 0.001 ) ... PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM induced IL-8 ( P < 0.0001 ) and GM-CSF ( P < 0.01 ) release ... The p38 MAP kinase inhibitor SB-203580 increased CAM induced IL-8 release ( P < 0.001 ), and the c-jun NH2-terminal kinase inhibitor SP-600125 had no effect on IL-8
Ito et al., J Biol Chem 1991 : These results indicate that calmodulin is required for the interleukin 1-enhanced synthesis of TIMP but it is a suppressor for the synthesis of proMMPs-1 and -3
Sohn et al., Respiration 2007 : Calmodulin inhibitor ( calmidazolium ) and tyrosine kinase inhibitor ( genistein ) almost completely blocked IL-8 release by HDM
Sugiyama et al., Clin Exp Immunol 2007 : Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro effects of clarithromycin (CAM) , azithromycin ( AZM ) and midecamycin ( MDM ) on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10, IL-6, interferon (IFN)-gamma, IL-12p40, tumour necrosis factor (TNF)-alpha ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation
Yamazaki et al., J Infect Chemother 2012 : CAM inhibited the release of chemotactic activity and the production of interleukin (IL)-8 and macrophage chemotactic protein (MCP)-1
Yokota et al., Mediators Inflamm 2012 (Respiratory Syncytial Virus Infections) : Clarithromycin (CAM) , which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV induced production of interleukin-6, interleukin-8 , and regulated on activation, normal T-cell expressed and secreted ( RANTES )
Cai et al., Immunobiology 2013 (Cryptogenic Organizing Pneumonia) : CAM and AZM induced a dose dependent suppression of spontaneous TNF-a, sTNFR2, IL-6, IL-8 and CCL18 production ( p < 0.05 ) ... CAM and AZM significantly and dose-dependently attenuated the LPS stimulated production of sTNFR1, sTNFR2, IL-8 and CCL18 ( p < 0.05 )
Shen et al., J Nutr 2013 (Inflammation...) : U73122 attenuated 18 : 2t10, c12 mediated insulin resistance within 48 h and suppression of the mRNA levels of peroxisome proliferator activated receptor ( PPAR ) ?, insulin stimulated glucose transporter-4, acetyl-CoA carboxylase-1, and stearoyl-CoA desaturase-1, and the protein levels of PPAR? within 18-24 h. U73122 inhibited 18 : 2t10, c12 mediated induction of the inflammatory related genes calcium/calmodulin dependent protein kinase-ß, cyclooxygenase-2, monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 , secretion of IL-6 and IL-8, and the activation of extracellular signal related kinase, c-Jun N-terminal kinase, and c-Jun within 18-24 h
Ojima et al., Biochim Biophys Acta 1989 : Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblasts