Zhao et al., J Leukoc Biol 2007
:
The exchange activity of P-Rex1 is synergistically activated by the binding of PIP3 and betagamma subunits of heterotrimeric G proteins in vitro, suggesting that the association of P-Rex1 with membranes is a prerequisite for cellular activation
Wertheimer et al., Cell Signal 2012
(Breast Neoplasms...) :
P-Rex1 is activated by the PI3K product PIP3 and Gß? subunits, and integrates signals from ErbB receptors and GPCRs