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EGF — PLD2
Pathways - manually collected, often from reviews:
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PLD2
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EGF
(increases, EGF Activity)
Evidence: A role for PLD in cell proliferation is indicated from reports showing that PLD activity is elevated in response to platelet-derived growth factor (PDGF; 6), fibroblast growth factor (7, 8), epidermal growth factor (EGF; 9), insulin (10), insulin-like growth factor 1 (11), growth hormone (12), and sphingosine 1-phosphate (13). PLD activity is also elevated in cells transformed by a variety of transforming oncogenes including v-Src (14), v-Ras (15, 16), v-Fps (17), and v-Raf (18).
Text-mined interactions from Literome
Hornia et al., Mol Cell Biol 1999
(Cell Transformation, Neoplastic) :
Interestingly, both rottlerin and
EGF induced substantial
increases in
phospholipase D ( PLD ) activity, which is commonly elevated in response to mitogenic stimuli
Lu et al., Mol Cell Biol 2000
(Cell Transformation, Neoplastic) :
The
activation of
PLD by
EGF in these cells was dependent upon both Ras and RalA
Chen et al., IUBMB Life 2001
:
These results indicated that PKC, at least PKC-delta and Ca2+ dependent PKC-alpha or -betaI, plays an important role in BK-induced but not
EGF induced
PLD activation in A-431 cells
Min et al., Mol Cells 2001
(Carcinoma, Squamous Cell) :
Activation of
PLD by H2O2 and
EGF nearly correlated with tyrosine phosphorylation of the protein in PLD1 immune complexes
Kim et al., J Biol Chem 2003
:
We found that ADP-ribosylation factor 4 (ARF4) interacts with the intracellular part of EGFR and mediates the
EGF dependent cellular activation of
phospholipase D2 (PLD2) but does not mediate the activation of PLD1
Andresen et al., Hypertension 2003
(MAP Kinase Signaling System) :
However,
EGF stimulation does not
activate phospholipase D or generate PA
Jang et al., J Biol Chem 2003
:
The interaction between PLC-gamma1 and
PLD2 is
EGF stimulation
dependent and potentiates EGF induced inositol 1,4,5-trisphosphate ( IP ( 3 ) ) formation and Ca ( 2+ ) increase
Ahn et al., Mol Cell Biol 2003
(Carcinoma, Squamous Cell) :
Moreover,
epidermal growth factor induced tyrosine phosphorylation of
PLD2 and its interaction with c-Src in A431 cells
Lee et al., J Biol Chem 2004
:
EGF treatment triggered the dissociation of Munc-18-1 from PLD when
PLD was
activated by
EGF ... The dissociation of the endogenous interaction between Munc-18-1 and PLD, and the
activation of
PLD by
EGF were also observed in primary cultured chromaffin cells
Cook et al., Biochem J 1992
:
Pre-treatment of Swiss 3T3 cells with the EGF-receptor tyrosine kinase inhibitor AG18 selectively inhibited
EGF stimulated
PLD activity ; bombesin stimulated PLD activity was unaffected
Wright et al., Biochem J 1992
:
Activation of
phospholipase D by alpha-thrombin or
epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol ... We investigated the
effect of alpha-thrombin and
epidermal growth factor (EGF) on cellular
PLD activity in order to determine the role of this enzyme in mitogen induced increases in phosphatidic acid and sn-1,2-diacylglycerol ... These data indicate that in quiescent IIC9 cells : ( a ) alpha-thrombin or
EGF rapidly and transiently
activates a
PLD ; ( b ) although this activation is responsible for part of the mitogen induced increases in phosphatidic acid, it does not contribute to induced increases in sn-1,2-diacylglycerol ; and ( c ) activation of this enzyme appears to be involved in the formation of a novel lipid generated in response to alpha-thrombin, but not EGF, in IIC9 fibroblasts
Lee et al., Cell Signal 2008
:
We found that a Cdk5 inhibitor, roscovitine, and dominant negative Cdk5 inhibited
EGF dependent
PLD2 activation and insulin secretion
Fisher et al., J Cell Physiol 1991
:
To identify the presence of
EGF induced
phospholipase D activity, cells were labelled with exogenous [ 3H ] 1-0-hexadecyl, 2-acyl phosphatidylcholine and its conversion to phosphatidic acid in response to EGF determined ... Consistent with the presence of
EGF induced
phospholipase D activity, treatment of cells with EGF, in the presence of [ 14C ] ethanol, resulted in the rapid formation of [ 14C ] phosphatidylethanol, the product of phospholipase D-catalyzed transphosphatidylation
Morrison et al., J Cell Physiol 1995
:
Neither basic Fibroblast Growth Factor (bFGF) or
Epidermal Growth Factor (EGF) increased
PLD activity
Yeo et al., J Biol Chem 1995
:
Stimulation of
phospholipase D by
epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells ...
EGF , basic fibroblast growth factor (bFGF), bombesin, and platelet derived growth factor ( PDGF )
activated PLD as measured by transphosphatidylation of butanol to phosphatidylbutanol ...
Activation of
PLD by
EGF was inhibited dose dependently by the PKC inhibitors bis-indolylmaleimide and Ro-31-8220, which also inhibited the effects of bFGF, bombesin, and PDGF ... In summary, all of the results of the study indicate that
PLD activation by
EGF is downstream of PtdIns ( 4,5 ) P2-hydrolyzing phospholipase and is dependent upon subsequent PKC activation
Dunlop et al., Biochim Biophys Acta 1993
:
We investigated the
activation of
phospholipase D ( PLD ) by a PKC activator, phorbol myristate acetate ( PMA ) and by
EGF in CHO cells transfected with the full-length EGF receptor
Budnik et al., FEBS Lett 1993
:
We propose, therefore, that phosphatidic acid may act as an intracellular second messenger linking
EGF mediated activation of
phospholipase D with the sensitization of LH receptor coupled adenylate cyclase signalling system
Mizunuma et al., Biochim Biophys Acta 1993
:
The
PLD was shown to be
activated by phorbol, 12-myristate, 13-acetate ( PMA ), calcium ionophore A23187, oxytocin, bombesin and bradykinin, but not by platelet activating factor (PAF) and
epidermal growth factor (EGF)
Kaszkin et al., Biochem J 1996
(Carcinoma, Squamous Cell) :
In the case of
EGF induced activation of a
phospholipase D the amount of phosphatidic acid is only slightly decreased in the presence of a primary alcohol
Hess et al., J Biol Chem 1997
:
In
response to
epidermal growth factor (EGF) ,
PLD activity was greatly increased in Rat1 fibroblasts expressing wild type Rac1 ( wtRac1 ), and completely abrogated in cells expressing dominant negative N17Rac1, consistent with Rac1 mediating the action of this growth factor ... In summary, these data indicate a major role for Rac1 in the
activation of
PLD by
EGF , but not PDGF or protein kinase C
Zhang et al., Curr Eye Res 1998
:
The aim of the present study was to investigate the
effect of
epidermal growth factor (EGF) on
PLD activity in rabbit corneal epithelial cells ( RCEC ) ... Under the same experimental conditions, the inhibitor had no effect on
EGF stimulated
PLD activity ... Down-regulation of PKC or treatment of the cells with RO31-8220, a PKC inhibitor, inhibited the PMA- but not
EGF stimulated
PLD activity ... Incubation of the cells with wortmannin, a PI 3-kinase inhibitor, abolished the EGF stimulated PI 3-kinase activity, but potentiated the
EGF stimulated
PLD activity ... These results indicate that
EGF stimulates
PLD activity in RCEC by a mechanism that involves tyrosine phosphorylation of a protein ( s ) in the cascade of biochemical reactions initiated by EGF-receptor interaction, and it is not dependent on concurrent activation of PKC, PLC, or PI 3-kinase in these cells
Carpio et al., Prostaglandins Leukot Essent Fatty Acids 1998
(Calcium Signaling) :
In summary, PA stimulates rat calvarial osteoblastic cell proliferation and mobilization of [ Ca2+ ] i using extracellular pools, and
EGF 's mitogenic effect on these cells
requires activation of
PLD
Carpio et al., J Bone Miner Res 1998
:
This study determined the
effects of
epidermal growth factor (EGF) on
PLD activity in normal rat osteoblastic cells
Slaaby et al., J Biol Chem 1998
:
Mutation of this residue to phenylalanine enhanced basal activity almost 2-fold, but did not alter the magnitude of the
EGF mediated increase in
PLD2 activity