◀ Back to EGF

EGF — SH3KBP1

Pathways - manually collected, often from reviews:

• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: EGF R/SRC/EGF complex (EGFR-SRC-EGF) → SH3BP1 (SH3KBP1) (protein ubiquitination, collaborate)
• Reactome Reaction: EGF → SH3KBP1 (direct_complex)
• Reactome Reaction: EGF → SH3KBP1 (indirect_complex) Rosenthal et al., J Biol Chem 1999, Soubeyran et al., Nature 2002, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
• Reactome Reaction: EGF → SH3KBP1 (reaction) Soubeyran et al., Nature 2002, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Schmidt et al., Oncogene 2006

Text-mined interactions from Literome

Take et al., Biochem Biophys Res Commun 2000 : Our results suggest that CIN85 may play a specific role in the EGF receptor mediated signaling cascade via its interaction with c-Cbl
Kowanetz et al., J Biol Chem 2003 : Identification of a novel proline-arginine motif involved in CIN85 dependent clustering of Cbl and down-regulation of epidermal growth factor receptors