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IL6 — SAA2

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 1999 : Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha ( 1B ) -adrenergic receptor ( alpha ( 1B ) AR ) agonist phenylephrine ( PE ) significantly inhibited interleukin 6 (IL-6) induced STAT3 binding, tyrosine phosphorylation, and IL-6 induced serum amyloid A mRNA expression
Hayashi et al., Proc Natl Acad Sci U S A 2002 (Bone Resorption) : Not only did MDL-A markedly inhibit IL-6- and IL-11 induced osteoclastogenesis in vitro, but it also inhibited IL-6 stimulated serum amyloid A production and bone resorption in an experimental model of postmenopausal osteoporosis in vivo by a different mechanism from that of 17beta-estradiol
Thorn et al., Amyloid 2002 : The Saa1 and Saa2 promoters are strongly induced by IL-6 , with synergistic upregulation of Saa2, but not of Saa1, by IL-1 or TNF
Hagihara et al., Biochem Biophys Res Commun 2004 : Either IL-6 and IL-1beta or IL-6 and TNFalpha, but not IL-1beta and TNFalpha, induced the synergistic induction of SAA1 and SAA2 genes
Gervois et al., J Biol Chem 2004 (Acute-Phase Reaction) : PPARalpha prevents the IL-6 induced expression of the positive APR genes fibrinogen-alpha, -beta, -gamma, haptoglobulin, and serum amyloid A and the IL-6 induced suppression of the negative APR gene, major urinary protein
Thorn et al., Scand J Immunol 2004 : Here, we examine the roles of TNF-alpha, interleukin-6 (IL-6) and GCs on the transcriptional regulation of the two human A-SAA genes ( SAA1 and SAA2 ) and show that these stimuli have different effects on the SAA1 and SAA2 promoters in HepG2 hepatoma and KB epithelial cell lines
Kuzuhara et al., Eur J Pharmacol 2006 (Liver Failure) : We examined whether the 22beta-methoxyolean-12-ene-3beta,24 ( 4beta ) -diol ( ME3738 ) -mediated selective induction of interleukin-6 increased alpha1-acid glycoprotein and serum amyloid A expression, and whether these proteins protected against liver injury in vitro and in vivo
Mackiewicz et al., Biochem J 1988 : Comparison of these findings with those in human hepatoma cell lines, in which interleukin-1 does not induce serum amyloid A synthesis, suggests that the effect of interleukin-1 on serum amyloid A synthesis may be indirect
Weinstein et al., J Trauma 1987 (Acute-Phase Reaction...) : The effect of interleukin-1 on mouse liver serum amyloid A mRNA levels was investigated
Moshage et al., Biochem Biophys Res Commun 1988 : The effect of interleukin-1 , interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes ... These findings suggest that IL-6 plays a key role in the stimulation of synthesis of serum amyloid A and C-reactive protein by the human liver cells
Jiang et al., J Immunol 1995 : Induction of human serum amyloid A in Hep 3B cells by IL-6 and IL-1 beta involves both transcriptional and post-transcriptional mechanisms
Xia et al., Int J Biochem Cell Biol 1997 (Acute-Phase Reaction) : Our previous data suggest that the synergistic induction of the major acute phase reactant serum amyloid A2 (SAA2) expression by interleukin-1 (IL-1) and interleukin-6 (IL-6) is mediated by two families of transcription factors, namely NF-kappa B and C/EBP ... These results suggest the NF-kappa B and C/EBP may form a new complex of transcription factors that mediates the synergistic induction of SAA2 by IL-1 and IL-6