Gene interactions and pathways from curated databases and text-mining

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AKT2 — BTC

Text-mined interactions from Literome

Kim et al., FASEB J 2003 (Neovascularization, Pathologic) : BTC induced ERK1/2 and Akt phosphorylation in a dose- and time dependent manner
Shin et al., Circ Res 2003 (Arteriosclerosis) : BTC rapidly induced the phosphorylation of Akt , GSK3alpha/beta, and two FoxO factors, FKHR and AFX, in a dose- and time dependent manner
Mifune et al., Am J Physiol Cell Physiol 2004 : In postreceptor signal transduction, BTC stimulated phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, Akt , and p38 mitogen activated protein kinase ( MAPK )
O-charoenrat et al., Int J Cancer 2004 (Carcinoma, Squamous Cell...) : BTC induced ERK1/2, JNK/SAPK and Akt phosphorylation with differing kinetics but not p38 kinase ... Taken together, our data show that BTC induces MMP-9 production and invasion primarily through activation of EGFR, MAPK and PI3K/Akt in HNSCC cells