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AKT2 — IL22
Text-mined interactions from Literome
Brand et al., Am J Physiol Gastrointest Liver Physiol 2006
(Crohn Disease...) :
IL-22 binding to its receptor complex
activates STAT1/3,
Akt , ERK1/2, and SAPK/JNK MAP kinases
Brand et al., Am J Physiol Gastrointest Liver Physiol 2007
(Disease Models, Animal...) :
Binding of
IL-22 to its receptor complex expressed on human hepatic cells and primary human hepatocytes
resulted in the activation of MAPKs,
Akt , and STAT proteins
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Doroshow et al., Biochem Pharmacol 2012
:
Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and
Akt signaling
mediated by IL-4, IL-6, IL-13, and
IL-22 , possibly due to a concomitant increase in tumor cell phosphatase activity
Mitra et al., Cytokine 2012
(Arthritis...) :
In NHEK and FLS,
IL-22 significantly
induced phosphorylation of
Akt and mTOR which was effectively blocked by Rapamycin and NVP-BEZ235