Whitacre et al., Clin Cancer Res 2000
(Colonic Neoplasms) :
Our results suggest that : ( a ) Pc 4-PDT is effective in the treatment of SW480 human colon cancer xenografts independent of p53 status ; ( b ) PARP cleavage may be mediated by caspase-9 and caspase-3 activation in the Pc 4-PDT treated tumors ; and ( c ) p38 phosphorylation may be a trigger of apoptosis in response to PDT in vivo in this tumor model
Azizuddin et al., Int J Oncol 2001
(Carcinoma, Squamous Cell) :
In addition, in the presence of Pc 4-PDT or rhTNF, caspase-3 activity and apoptosis were induced