◀ Back to TLR2
IFNB1 — TLR2
Text-mined interactions from Literome
Schilling et al., J Immunol 2002
:
TLR4, but not
TLR2 , agonists can
induce IFN-beta expression via a mechanism that requires the adapter protein Toll-IL-1R domain containing adapter protein ( TIRAP ) /myeloid differentiation protein 88 ( MyD88 ) adapter-like ( Mal ), but not the adapter protein MyD88
Kaisho et al., Curr Mol Med 2003
:
TLR2 can not
induce IFN-alpha or
IFN-beta , but TLR4 can lead to IFN-beta production ... Meanwhile,
TLR3 , TLR7, and TLR9 can
induce both IFN-alpha and
IFN-beta
Aksoy et al., Eur J Immunol 2005
:
In the same models of DC activation, PI3K inhibition increased DNA binding activity of NF-kappaB, but not interferon response factor (IRF)-3, the key transcription factors required for
TLR mediated
IFN-beta synthesis
Zhu et al., Blood 2007
:
Innate immunity against vaccinia virus is mediated by
TLR2 and
requires TLR independent production of
IFN-beta
Koga et al., J Immunol 2006
(Chagas Disease) :
TLR dependent induction of
IFN-beta mediates host defense against Trypanosoma cruzi ... These findings suggest that
TLR dependent expression of
IFN-beta is involved in resistance to T. cruzi infection through the induction of IRG47
Colonna et al., Eur J Immunol 2007
:
These results demonstrate that
TLR induce IFN-alpha or
IFN-beta responses by activating distinct IRF, depending on the TLR ligand and the cell type
Rudd et al., Viral Immunol 2007
(Respiratory Syncytial Virus Infections) :
The data demonstrate that production of
IFN-beta , but not IFN-alpha, in RSV infected wild type DCs
promotes chemokine production and
toll-like receptor ( TLR ) expression, while limiting IL-12 production
Cross et al., J Immunol 2008
:
CD45 regulates
TLR induced proinflammatory cytokine and
IFN-beta secretion in dendritic cells
Cao et al., Nat Immunol 2008
:
Thus, mTOR signaling is crucial in
TLR mediated
IFN-alpha/beta responses by pDCs
Ciencewicki et al., J Interferon Cytokine Res 2009
:
Interestingly, although influenza infection results in
IFN-beta release both toward the apical and basolateral sides of the epithelium,
TLR3 expression is only
enhanced in cells stimulated with IFN-beta from the basolateral side
Chang et al., Virology 2009
:
We further demonstrate that the HCMV derived interleukin 10 (IL-10) homolog functions similar to cellular IL-10 and broadly inhibits
TLR induced transcriptional activation of
IFN-alpha/beta genes in plasmacytoid dendritic cells ( PDCs ), a major type I IFN-producer in vivo that is highly resistant to HCMV infection in vitro
Yu et al., J Allergy Clin Immunol 2009
(Common Variable Immunodeficiency) :
These TLR defects are restricted because CVID PBMCs stimulated with TLR ligands produced normal amounts of TNF-alpha, IL-6, and IL-12
; TLR3 mediated expression of
IFN-beta by CVID fibroblasts was normal
Renneson et al., Eur J Immunol 2009
:
Neonatal myeloid DC were shown to be deficient in
IFN-beta and IL-12 synthesis in
response to
TLR triggering
Kaiser et al., J Exp Med 2009
:
Here, we investigated the role of the TPL-2 signaling pathway in
TLR induction of
interferon-beta (IFN-beta) and interleukin-10 (IL-10) in these cell types
Wang et al., J Clin Invest 2009
(Enterocolitis...) :
In contrast,
TLR3 activated expression of
IFN-beta , a TRIF dependent response, was normal in Hfe KO macrophages and was unaffected by iron chelation
Burns et al., J Immunol 2010
(Bacteroidaceae Infections) :
Proinflammatory cytokine production in response to P. gingivalis infection depends on TLR2, but it does not require MyD88 or
TLR/IL-1R-domain containing adaptor
inducing IFN-beta
Gabhann et al., J Immunol 2010
:
SHIP-1-deficient macrophages display enhanced
TLR induced
IFN-beta production, and overexpression of SHIP-1 negatively regulates the ability of TLR3 and its adaptor, Toll/IL-1 receptor domain containing adaptor inducing IFN-beta, to induce IFN-beta promoter activity, indicating that SHIP-1 negatively regulates TLR induced IFN-beta production
Hartiala et al., J Immunol 2010
:
The data show that 1 ) effective signaling via p38 MAPK ( and STAT1 and NF-kappaB ) is needed for CD38 expression and 2 )
TLR2 stimulation, as opposed to TLR4 stimulation, does not
induce IFN-beta autocrine loop dependent expression of CD38 and secretion of IL-12
Simmons et al., J Immunol 2010
:
Furthermore, M. tuberculosis and
TLR2 agonists
inhibited induction of
IFN-alpha/beta and DC cross processing by CpG DNA
Cervantes et al., Proc Natl Acad Sci U S A 2011
:
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves
Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8 mediated
induction of
IFN-beta