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FOXO1 — MST1
Text-mined interactions from Literome
Lehtinen et al., Cell 2006
:
MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins,
promotes FOXO nuclear translocation, and thereby induces cell death in neurons
Anand et al., Biochemistry 2008
:
We also identify autophosphorylation sites within the MST1 regulatory region and show that both regulatory region phosphorylation and
MST1 dimerization
contribute to
FoxO phosphorylation
Yuan et al., J Biol Chem 2009
:
Here, we show that
MST1 induced phosphorylation of
FOXO1 at serine 212, corresponding to serine 207 in FOXO3, disrupts the association of FOXO1 with 14-3-3 proteins ... Accordingly,
MST1 mediates the nuclear translocation of
FOXO1 in primary rat cerebellar granule neurons that are deprived of neuronal activity ... We also find a requirement for MST1 in cell death of granule neurons upon withdrawal of growth factors and neuronal activity, and
MST1 induces cell death in a
FOXO1 dependent manner
Bi et al., J Biol Chem 2010
:
We also find the S82A ( serine mutated to alanine ) diminishes
MST1 activation and its
effect on the
FOXO transcription activity