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SIRT7 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
van Leeuwen et al., Adv Cancer Res 2009
(Neoplasms) :
Preliminary observations also suggest that
sirtuin mediated modulation of
p53 can also take place indirectly through changes in cellular processes ( e.g., nucleolar function and p300 activity ) known to affect p53
Lynch et al., PloS one 2010
:
Thus,
SIRT1 mediated inhibition of
p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing
van Leeuwen et al., Mol Cancer Ther 2013
:
These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective
activation of
p53 by small-molecule
sirtuin inhibitors