Nourse et al., Nature 1994
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During T-cell mitogenesis, antigen-receptor signalling promotes synthesis of cyclin E and its catalytic partner, Cdk2, and interleukin-2 (IL-2) signalling activates cyclin E/Cdk2 complexes
Sakaida et al., AIDS Res Hum Retroviruses 1998
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The effect of V3-BH10 on the IL-2 induced expression of G1 cyclins, Cdk inhibitors, and phosphorylation of retinoblastoma protein ( pRb ) was tested by immunoblotting, using the IL-2 dependent CD4 positive cell line Kit 225 ... Furthermore, IL-2 dependent kinase activity of the cyclin E-Cdk2 complex was investigated with histone H1 as a substrate