Ilan et al., Int J Biochem Cell Biol 2006
(Disease Progression...) :
Transcriptional activity of the heparanase promoter is stimulated by demethylation, early growth response 1 (EGR1) transcription factor , estrogen, inflammatory cytokines and inactivation of p53
An et al., Mol Cell Biochem 2011
(Diabetic Nephropathies) :
Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor ... These results suggest that AGEs could induce heparanase expression in HMVECs by RAGE and predominantly through activation of the FOXO4 transcription factor