Gene interactions and pathways from curated databases and text-mining

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HRAS — LPA

Text-mined interactions from Literome

Nebesio et al., Glia 2007 (Disease Models, Animal...) : Furthermore, LPA induced a higher level of Ras-GTP and Akt phosphorylation in Nf1-/- SCs as compared to WT cells
Luttrell et al., J Biol Chem 1995 : The IGF1, LPA , and EGF receptor mediated signals are all sensitive to inhibitors of tyrosine protein kinases, require p21ras activation, and are independent of protein kinase C
van Corven et al., Proc Natl Acad Sci U S A 1993 : Thus, a heterotrimeric G protein of the Gi subfamily regulates activation of p21ras by LPA and thrombin, possibly through an intermediary tyrosine kinase
Hordijk et al., J Biol Chem 1994 : Furthermore, LPA rapidly activates p21ras through a pertussis toxin-sensitive pathway