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CAPN2 — CXCL10

Text-mined interactions from Literome

Shiraha et al., J Cell Biol 1999 : IP-10 also prevented EGF- induced calpain activation ( reduced by 71 +/- 7 % ) ... That this inhibition of EGF induced calpain activity was secondary to IP-10 initiating a cAMP-protein kinase A-calpain cascade is supported by the following evidence : ( a ) the cell permeant analogue 8- ( 4-chlorophenylthio ) -cAMP ( CPT-cAMP ) prevented EGF induced calpain activity and motility ; ( b ) other ELR negative CXC chemokines, monokine induced by IFN-gamma and platelet factor 4 that also generate cAMP, inhibited EGF induced cell migration and calpain activation ; and ( c ) the protein kinase A inhibitor Rp-8-Br-cAMPS abrogated IP-10 inhibition of cell migration, cell detachment, and calpain activation
Bodnar et al., Circ Res 2006 : Using Rp-8-Br-cAMP, we show blocking PKA reversed the IP-10 inhibition of VEGF induced m-calpain activity