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FOXO4 — SIRT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by HDAC Class III: FOXO4 (FOXO4) → SIRT1 (SIRT1) (modification, collaborate)
• NCI Pathway Database Signaling events mediated by HDAC Class III: FOXO4 (FOXO4) → SIRT1/FOXO4 complex (FOXO4-SIRT1) (modification, collaborate)
  
• NCI Pathway Database Signaling events mediated by HDAC Class III: SIRT1 (SIRT1) → SIRT1/FOXO4 complex (FOXO4-SIRT1) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FOXO4 — SIRT1 (physical association, affinity chromatography technology) van der Horst et al., J Biol Chem 2004*
• IRef Intact Interaction: FOXO4 — SIRT1 (physical association, anti tag coimmunoprecipitation) van der Horst et al., J Biol Chem 2004*
• IRef Intact Interaction: FOXO4 — SIRT1 (deacetylation reaction, deacetylase assay) van der Horst et al., J Biol Chem 2004*

Text-mined interactions from Literome

Oh et al., Mol Pharmacol 2010 : Overexpression of SIRT1 enhanced both FoxO reporter activity and nuclear levels of FoxO1
Xiong et al., J Biol Chem 2011 : Consistently, FoxO1 overexpression increases SIRT1 expression, and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels in vascular smooth muscle cells and HEK293 cells
Rizki et al., PLoS Genet 2011 : The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response ; and complex regulation of DAF-16/FOXO by SIR-2.1/SIRT1 is central to appropriate biological outcomes
Parker et al., J Neurosci 2012 : In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity, and this protection requires the longevity promoting factor daf-16/FOXO