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Mollapour et al., Blood 2001
(MAP Kinase Signaling System) :
PD98059 inhibited the activation of p42 ( ERK2 ) by GM-CSF , TNF-alpha, and FMLP, but it did not inhibit FMLP stimulated superoxide production in either unprimed or primed neutrophils
Hallsworth et al., Am J Respir Crit Care Med 2001
(Asthma...) :
GM-CSF release is p42/p44 ERK dependent and is tonically suppressed by a mechanism that is partially dependent on p38 MAP kinase, though direct inhibition of cyclooxygenase (COX) activity due to poor inhibitor selectivity may also contribute
Dohgu et al., Journal of neuroinflammation 2011
:
These results show that p44/42 and p38 MAPK signaling pathways mediate the LPS enhanced release of IL-6 and GM-CSF