◀ Back to JUN
JUN — SOCS3
Text-mined interactions from Literome
Miao et al., Mol Cell Neurosci 2008
(Neuroblastoma) :
Mutant
SOCS3 increased
AP-1 ( activator protein ) transcriptional activity and JNK ( c-Jun N-terminal kinase ) activity and SOCS3 bound to the scaffolding protein, JNK interacting protein-1 : these observations provide a plausible explanation for the enhancement by mutant SOCS3 of the actions of CNTF
Wiejak et al., Mol Pharmacol 2012
:
In addition
AP-1 , pSTAT, and SP1/SP3 binding sites were
required for ERK dependent, PMA stimulated
SOCS-3 gene activation
Wiejak et al., Cell Signal 2012
:
The PKC inhibitors, GF-109203X, Gö-6983 and Ro-317549, were all found to inhibit
AP-1 transcriptional activity, transcriptional activation of this minimal SOCS-3 promoter and
SOCS-3 gene
induction in HUVECs ... The JNK dependent hyper-phosphorylation of c-Jun in response to Ro-317549 treatment of HUVECs does therefore not interfere with its ability to inhibit c-Jun activity and acts as an effective inhibitor of
c-Jun dependent
SOCS-3 gene induction