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EGFR — HSPG2

Text-mined interactions from Literome

Haugh et al., Biotechnol Bioeng 2000 : We have formulated a simple mathematical model of a key signaling pathway required for regulated migration of fibroblasts and other cell types : activation of the intracellular enzyme phospholipase C (PLC) mediated by epidermal growth factor receptor (EGFR) and a multitude of other transmembrane receptors
Ramadurai et al., Am J Physiol Lung Cell Mol Physiol 2003 : PLC-gamma activation by EGFR in fetal lung fibroblasts may be involved in EGF control of lung development
Hassan et al., Regul Pept 2004 (Prostatic Neoplasms) : The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor ( U73122 ), PKC-inhibitors ( bisindolylmaleimide, staurosporine, rottlerin ), MEK inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin, LY 294002 )
Bourguignon et al., J Biol Chem 2006 (Carcinoma, Squamous Cell...) : Overexpression of the LARG-PDZ domain also functions as a dominant negative mutant ( similar to the PLC/Ca2+-calmodulin dependent kinase II ( CaMKII ) and EGFR/MAPK inhibitor effects ) to block HA/CD44 mediated signaling events ( e.g. EGFR kinase activation, Ras/RhoA co-activation, Raf-ERK signaling, PLC epsilon mediated inositol 1,4,5-triphosphate production, intracellular Ca2+ mobilization, CaMKII activity, filamin phosphorylation, and filamin-actin binding ) and to abrogate tumor cell growth/migration ... Taken together, our findings suggest that CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII mediated cytoskeleton function and in head and neck squamous cell carcinoma progression
Ou et al., J Biol Chem 2012 (Glioma...) : Moreover, Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin mediated migration and invasion depend on epidermal growth factor receptor induced PLC-? and STAT3 signaling pathways
Chen et al., J Cell Biol 1996 : We used signaling restricted EGFR mutants expressed in receptor-devoid NR6 fibroblast cells to investigate whether EGFR activation of PLC causes gelsolin mobilization from the cell membrane in vivo and whether this translocation facilitates cell movement
Yang et al., Biochem Pharmacol 1997 : Since recent studies suggest that activation of phospholipase C (PLC) could increase the phosphorylation of P-gp, and activation of the EGFR would also activate PLC , we investigated whether the effect of epidermal growth factor (EGF) on the phosphorylation of P-gp was mediated through PLC
Van Epps-Fung et al., Endocrinology 1997 : Activation of EGFR overexpressing 3T3-L1 adipocytes leads to a 3.4 +/- 1.2-fold stimulation of PLC activity over basal levels vs. only 1.06 +/- 0.01-fold stimulation by insulin
Amsler et al., Am J Physiol 1999 : We report here that tyrosine phosphorylation of phospholipase C-gamma (PLC-gamma) was induced only when basolateral EGFR was activated