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CD8B — IFNG

Text-mined interactions from Literome

El-Sheikh et al., J Autoimmun 1999 (Diabetes Mellitus, Type 1) : Both CD4 ( + ) and CD8 ( + ) T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats ... Depletion of either CD4 ( + ) or CD8 ( + ) T cells completely prevented IFN-gamma mRNA upregulation in islets of DP-BB rats above the low level expressed in islets of diabetes-resistant ( DR ) BB rats
Cousens et al., J Exp Med 1999 (Lymphocytic Choriomeningitis) : Under normal conditions of infections, the CD8 T cell IFN-gamma response was dependent on endogenous IFN-alpha/beta effects, but was IL-12 independent
Dobashi et al., Hepatology 1999 : In addition, liver MNC acquired a potent antitumor cytotoxicity by the SEB injection, and both NK cells and NK1 ( + ) T cells but not cluster of differentiation (CD)8 ( + ) T cells were responsible for the cytotoxicity as demonstrated by either in vivo or in vitro cell depletion experiments, and the NK-type cells were partly responsible for the increased serum IFN-gamma
Berger et al., Virology 2000 (Disease Models, Animal...) : ( 3 ) Production of interferon-gamma , obligatory for resolution of persistent infection, is dependent on the interaction of virus-specific CD4 ( + ) and CD8 ( + ) T cells
Tvinnereim et al., Infect Immun 2000 : IFN-gamma knockout ( KO ) mice were used to address the requirement for IFN-gamma in CD8 ( + ) T-cell priming against ( i ) a model exogenous antigen and ( ii ) secreted and nonsecreted L. monocytogenes antigens
Wu et al., Eur J Immunol 2000 : The presence of IFN-alpha or IFN-gamma in cultures enhanced IL-12Rbeta2 expression of CD4 ( + ) and CD8 ( + ) T cells
Grohmann et al., J Immunol 2001 (Diabetes Mellitus, Type 1) : IFN-gamma enhances the inhibitory activity of CD8 ( + ) DC on Ag presentation by the other subset, blocking the ability of IL-12 treated CD8 ( - ) DC to overcome suppression
Kumar et al., J Immunol Methods 2001 : In two monkeys studied in detail, the IFN-gamma response was focussed on a single 20-mer peptide, QGDGANAGQPQAQGDGANAG, and was dependent on CD4 ( + ), but not CD8 ( + ), T cells
Noël et al., Int Immunol 2001 : The production of both IFN-gamma and IL-2 following SEB stimulation was greatly impaired in co-cultures containing CD4 ( + ) T cells, but not CD8 ( + ) T cells, isolated from unresponsive animals
Grohmann et al., J Immunol 2001 : By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC, IL-12 and IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated CD8 ( + ) DC mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Cho et al., J Immunol 2001 : In this study, we demonstrated that non-APC-specific gene expressions induced significant CD8 ( + ) CTL and IFN-gamma producing cells and Ab responses, whereas APC-specific gene expressions led to moderate CTL and IFN-gamma-producers , but no Ab responses
Dunn et al., J Infect Dis 2002 : To study the dynamics of cytomegalovirus ( CMV ) immunity in healthy immunocompetent hosts, interferon-gamma producing CD4 and CD8 T cell responses in the presence or absence of CMV antigens were measured from 15 CMV-seropositive donors and 13 CMV-seronegative donors
Fadel et al., J Immunol 2002 (Retroviridae Infections...) : Despite the induction of significant anti-viral CD8+ mediated cytotoxic T lymphocyte and IFN-gamma responses, initial neonatal priming led to a lower frequency of virus-specific T cells compared with adult priming
Wang et al., Int J Cancer 2003 (Carcinoma...) : Depletion of CD8 ( + ) T cells suppressed the production of interferon-gamma
Liu et al., J Immunol 2003 : IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host
Ott et al., J Immunol Methods 2004 (Diabetes Mellitus, Type 1...) : CD4 and CD8 IFN-gamma responses to viral ( hepatitis C ) and autoimmune antigens ( islet cell ) were tested in 10 hepatitis C and 8 type 1 diabetic as well as healthy control subjects
Edwards et al., Eur J Immunol 2005 (Cryptococcosis...) : CD4 ( + ) and CD8 ( + ) T cells producing IFN-gamma increase in frequency, while those producing IL-5 decrease
Chen et al., Eur J Immunol 2005 (Dermatitis, Contact...) : However, by contrast with CCL5/RANTES, the diminished levels of IFN-gamma were likely due to the decreased number of skin infiltrating CD8 ( + ) T cells, since IFN-gamma production by antigen stimulated CD8 ( + ) T cells was comparable between wild-type and IL-15Ralpha ( -/- ) mice
Worgall et al., J Clin Invest 2005 (Pseudomonas Infections) : AdZ.Epi8 induced Epi8-specific IFN-gamma positive CD4 and CD8 T cell responses and resulted in protection against a lethal pulmonary challenge with agar encapsulated P. aeruginosa
Antonis et al., Vaccine 2006 (Respiratory Syncytial Virus Infections) : Functional IFN-gamma+ CD8 responses were slightly higher in the FI-bRSV vaccinated animals
Kapogiannis et al., AIDS Res Hum Retroviruses 2006 (HIV Infections...) : Among untreated patients with increased viral load there was a constant IFN-gamma CD8 response but a declining IFN-gamma CD4 response
Ramirez-Montagut et al., J Immunol 2006 (Disease Progression...) : Rejection requires CD4+, CD8+ , and NK1.1+ cells and is dependent on IFN-gamma and Fas ligand and independent of perforin
Fuse et al., J Virol 2006 : During long-term immune surveillance, the virus-specific CD8 ( + ) T cells were impaired in IFN-gamma production and secondary expansion and exhibited an altered phenotype
Russell et al., J Acquir Immune Defic Syndr 2007 : Net cumulative HIV-specific CD8 IFNgamma ELISpot assay responses were 13 % ( 95 % CI : -1 % to 26 % ) for recipients of vCP1452 alone and 16 % ( 95 % CI : 2 % to 29 % ) for recipients of vCP1452 plus rgp120
Hokeness et al., J Virol 2007 (Cytomegalovirus Infections) : Furthermore, CXCR3 functions augmented the hepatic accumulation of CD8 T-cell IFN-gamma responses to MCMV
Dobaño et al., Mol Immunol 2007 (Malaria) : Mutation of the P2 but not P9 or P10 anchor residues decreased protection and completely abrogated the antigen-specific CD8+ CTL activity and CD8+ dependent IFN-gamma responses to the immunodominant CD8+ epitope and overlapping CD8+/CD4+ epitope
Asavaroengchai et al., Biol Blood Marrow Transplant 2007 (Graft vs Host Disease) : These data show that IFN-gamma negatively regulates the CD8 T cell response by inhibiting cell division and promoting cell death and suggest that blockade of IFN-gamma could augment the severity of GVHD in patients undergoing allo-HCT
Ngai et al., Infect Immun 2007 (Disease Models, Animal...) : By using major histocompatibility complex class II-deficient or CD4-deficient mice, we found that the lack of CD4 T cells did not negatively affect primary or secondary CD8 T-cell IFN-gamma responses ... Moreover, during mycobacterial infection, CD8 T-cell IFN-gamma responses and activation are independent of CD4 T-cell activation
Osorio et al., Virus Res 2007 : IFN-gamma expression by CD4 ( + ) T cells was CD8 ( + ) T cells dependent
Saha et al., J Immunol 2007 (Disease Susceptibility...) : Both CD4 ( + ) and CD8 ( + ) T cells were involved in IFN-gamma and IL-10 production
Rifa'i et al., Int Immunol 2008 : CD8 ( + ) CD122 ( + ) Treg effectively suppressed the IFN-gamma production of the target cells of syngeneic mouse strains but not of allogeneic mouse strains with incompatible MHC
Chakravarty et al., Infect Immun 2008 : However, the requirement for CD8 ( + ) T-cell mediated IFN-gamma production in protective immunity to this pathogen has not been directly tested
Björck et al., J Immunol 2008 : IC-loaded pDC stimulate CD4 ( + ) T cells to proliferate and secrete a mixture of IL-4 and IFN-gamma, and they induce CD8 ( + ) T cells to secrete IL-10 as well as IFN-gamma ... In contrast, IC-loaded myDC induce both CD4 ( + ) and CD8 ( + ) T cells to secrete mainly IFN-gamma
Onishi et al., Br J Urol 1991 (Kidney Neoplasms) : The effect of IFN-gamma on TIL was an increase in CD3 ( pan-T cells ), especially an increase in CD8 ( cytotoxic/suppressor-T cells )
Ascon et al., Kidney Int 2009 (Kidney Diseases...) : Depletion of CD4 ( + ) and CD8 ( + ) T cells before ischemia caused less medullary damage and reduced kidney IFN-gamma expression, whereas their depletion following ischemia increased kidney IL-1beta ; however, depletion of these cells had no effect on histological damage to the kidney
Robinson et al., J Immunol 2009 (Disease Models, Animal...) : We conclude that liver damage in this model of fulminant autoimmune hepatitis is driven by CD4 ( + ) T cell production of IFN-gamma , is independent of both CD8 ( + ) T cells and the Fas ligand/Fas pathway, and is not explained by a lack of PD-L1 expression
Komai-Koma et al., Eur J Immunol 2009 : Moreover, CD8 ( + ) CD45RO ( + ) memory T cells constitutively expressed TLR4 and markedly enhanced IFN-gamma production when stimulated with LPS
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma , GM-CSF, TNF-alpha, and surface CD40L
Takeda et al., J Immunol 2009 (Asthma...) : Using adoptive transfer experiments, we found that suppression of AHR was mediated by Ag-specific CD8 ( + ) T cells and was dependent on IFN-gamma production by the transferred T cells
Todryk et al., Immunology 2009 : We observed a significant correlation between IFN-gamma responses to CD4-stimulatory, but not to CD8-stimulatory , recall antigens measured by these assays, suggesting a divergence in regulation
Tuettenberg et al., Exp Dermatol 2010 : Furthermore, stimulation of CD8 ( + ) T cells by peptide loaded CD40L-DC resulted in a substantial reduction of antigen-specific IFN-gamma production
Freeman et al., J Immunol 2010 (Pulmonary Disease, Chronic Obstructive) : In vitro stimulation of lung CD8 ( + ) T cells with IL-18 plus IL-12 markedly increased production of IFN-gamma and TNF-alpha, whereas IL-15 stimulation induced increased intracellular perforin expression
Contreras et al., J Immunol 2010 : Compared to CD26 ( - ) DCs, the sheep CD26 ( + ) DCs show 1 ) potent stimulation of allogeneic naive CD8 ( + ) T cells with high selective induction of the Ifngamma and Il22 genes ; 2 ) dominant efficacy in activating specific CD8 ( + ) T cells against exogenous soluble Ag ; and 3 ) selective expression of functional pathways associated with high capacity for Ag cross-presentation
Hodgkin et al., Cell Immunol 1990 : Interferon-gamma (IFN-gamma) caused almost complete inhibition of the CD4+/CD8- response but had no measurable effect on the growth of CD4-/CD8+ or CD4-/CD8- populations
Connick et al., J Acquir Immune Defic Syndr 2011 (HIV Infections) : HIV-specific CD8+ interferon-gamma responses increased after 48 weeks of ART ( P = 0.03 ), but failed to predict virologic success ( P = 0.18 )
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta
Dieli et al., Cytokine 1996 : This production of IFN-gamma is both antigen-specific and genetically ( MHC ) -restricted and is due to both CD8+ and CD4+ T cells
Vaidya et al., J Exp Med 1997 : Here, we isolate the gene for TLTF and demonstrate that the recombinant version of TLTF specifically induces CD8 ( + ), but not CD4 ( + ), T cells to secrete IFN-gamma
Su et al., J Immunol 1998 (Lymphocytic Choriomeningitis) : CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections : requirements for IL-2