◀ Back to IFNG
IFNG — SOCS1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SOCS1 (SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
SOCS1 (SOCS1)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
Reactome Reaction:
IFNG
→
SOCS1
(indirect_complex)
Yasukawa et al., EMBO J 1999*, Sasaki et al., Genes Cells 1999*
-
Reactome Reaction:
IFNG
→
SOCS1
(reaction)
Yasukawa et al., EMBO J 1999*, Sasaki et al., Genes Cells 1999*
Text-mined interactions from Literome
Park et al., Mol Endocrinol 2000
:
IFN-gamma up-regulated
SOCS-1 and SOCS-3 RNA and protein in FRTL-5 cells, as reported previously for nonthyroid cells
Sakamoto et al., Leukemia & lymphoma 2000
:
Among them, we have shown that
JAB/SOCS-1 is strongly
induced by
interferon-gamma and forced expression of JAB/SOCS-1I conferred cells interferon resistance
Saito et al., J Immunol 2000
:
IFN regulatory factor-1 mediated transcriptional
activation of mouse
STAT induced STAT inhibitor-1 gene promoter by
IFN-gamma ... Furthermore, forced expression of IRF-1 mimicked and that of IRF-2 inhibited the stimulatory
effect of
IFN-gamma on
SSI-1 gene transcription ... These results demonstrated that IRF-1, which is induced by activation of Stat1, mediated transcriptional
activation of the
SSI-1 gene by
IFN-gamma via VIRE
Metcalf et al., Proc Natl Acad Sci U S A 2000
(Myocarditis...) :
Comparison of SOCS-1 -/- IFN-gamma +/- mice with various control mice indicated that the development of tissue damaging T lymphocyte, macrophage, and eosinophil infiltrates required loss of SOCS-1 and the presence of some
IFN-gamma , but that the lung lymphoid infiltrates
required only loss of
SOCS-1 to develop
Cwikel et al., Exp Hematol 2001
:
Interferon-gamma had no effect on
CIS-3/JAB induction in these cells
Krebs et al., Stem Cells 2001
:
The analysis of socs1 ( -/- ) mice has revealed that
SOCS1 plays a key role in the negative regulation of
interferon-gamma signaling and in T cell differentiation
Turnley et al., Neuroreport 2001
:
SOCS1 expression by sensory neurons was
up-regulated by
IFNgamma
Federici et al., J Immunol 2002
(Dermatitis, Allergic Contact...) :
Suppressor of cytokine signaling
(SOCS)1 and SOCS3 are negative regulators of IFN-gamma signaling and are
induced in many cell types by
IFN-gamma itself or by other cytokines ... We show in this work that
SOCS1 , SOCS2, SOCS3, and cytokine-inducible SH2 containing protein mRNA were
up-regulated by
IFN-gamma in normal human keratinocytes, whereas only SOCS1 or SOCS1 and cytokine-inducible SH2 containing protein were induced by TNF-alpha or IL-4, respectively
Toniato et al., J Biol Chem 2002
:
Functionally, expression of TRIM8/GERP decreases the repression of
interferon-gamma signaling
mediated by
SOCS-1
Ding et al., J Immunol 2003
:
IL-10 induced
SOCS1 may directly
inhibit IL-10
IFN-gamma signaling, while inhibition of other proinflammatory cytokine responses may use additional IL-10R1 mediated mechanisms
Cornish et al., J Biol Chem 2003
:
SOCS-1-/-IFNgamma-/- mice also die before their wild type and IFNgamma-/- counterparts with a range of inflammatory conditions including pneumonia, gut infiltration, and skin ulceration, suggesting that
SOCS-1 controls not only
IFNgamma signaling, but also other immunoregulatory factors
Seifert et al., Exp Dermatol 2003
(Psoriasis) :
Using real time RT-PCR we demonstrated that IL-10 is neither able to induce its typical early gene product suppressor of cytokine signalling (SOCS) 3 nor to modulate the
interferone (IFN)-gamma induced expression of
SOCS 1 and 3
Dalpke et al., Eur J Immunol 2003
:
Overexpression of
SOCS-1 and, to a lesser extend, of SOCS-3 and CIS
inhibited IFN-gamma signaling as measured by activation of STAT1
Sato et al., Biochem Biophys Res Commun 2004
:
IFN-gamma induced
SOCS-1 regulates STAT6 dependent eotaxin production triggered by IL-4 and TNF-alpha ... We also demonstrated that
SOCS-1 , a potent inhibitory molecule of IL-4 signaling, was
induced by
IFN-gamma in STAT1 dependent manner
Qing et al., J Biol Chem 2005
:
Suppressor of cytokine signaling
(SOCS)-1 , the key negative regulator of interferon (IFN)-gamma dependent signaling, is induced in
response to
IFNgamma ...
SOCS-1 binds to and
inhibits the
IFNgamma receptor associated kinase Janus activated kinase (JAK) 2 and inhibits its function in vitro, but the mechanism by which SOCS-1 inhibits IFNgamma dependent signaling in vivo is not clear
Catlett et al., Nat Immunol 2005
:
Suppressor of cytokine signaling 1 ( Socs1 ) is
critical for the regulation of
interferon-gamma responses and T cell homeostasis
Osna et al., Hepatology 2005
:
In addition,
SOCS1 , a negative
regulator of
IFNgamma signaling and which is degraded by the proteasome, was stabilized by ethanol treatment, presumably because of inhibited proteasome activity
Yao et al., J Virol 2005
:
Silencing either
SOCS1 or SOCS3 by small interfering RNA dramatically
augments the production of
IFN-gamma in T cells, thereby abrogating the inhibitory effect of core
Hwang et al., Int J Hematol 2006
:
IFN-gamma up-regulated
Socs1 messenger RNA expression in normal CD34+ cells, which was further enhanced with the addition of HGFs
Dickensheets et al., Genes Immun 2007
:
Induction of SOCS-1 gene expression by IL-4 is STAT6 dependent, whereas
induction of
SOCS-1 by
IFN-gamma is STAT1 dependent
Shoda et al., Biochem Biophys Res Commun 2007
(Pulmonary Fibrosis) :
In contrast,
IFN-gamma suppressed the increase of collagen production induced by IL-4 in wild type fibroblasts but not
SOCS1-deficient fibroblasts, suggesting IFN-gamma acted exclusively via SOCS1 in this case
Waiboci et al., J Immunol 2007
:
Both Tkip and
SOCS1-KIR inhibited
IFN-gamma activation of Raw 264.7 murine macrophages and inhibited Ag-specific splenocyte proliferation
Fojtova et al., Br J Cancer 2007
(Melanoma...) :
The resistant subline ( termed WM 1158R ) differed from the sensitive subline ( WM 1158S ) by a constitutive expression of SOCS 3, lack or weak
SOCS 1-3 activation following
IFN-gamma , and short duration of cytokine activatory signal
Madonna et al., FASEB J 2008
:
Suppressor of cytokine signaling 1 inhibits
IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation ... Here we show that, after IFN-gamma stimulation,
SOCS1 inhibited
IFN-gamma receptor and STAT1 phosphorylation but maintained ERK1/2 activation
Takahashi et al., Cancer Sci 2008
:
Taking into account the synergistic effect of pshSOCS-1 and IFN-gamma on the growth of B16-BL6 cells, these findings suggest that
IFN-gamma induced high
SOCS-1 gene expression in B16-BL6 cells significantly interferes with the antiproliferative effect of IFN-gamma
Koelsche et al., Mol Immunol 2009
:
Altering the subcellular localization of
SOCS1 by mutating clusters of arginine residues within the NLS did not affect the inhibition of interferon mediated STAT1 tyrosine-phosphorylation, but surprisingly led to impaired inhibitory activity of STAT mediated reporter gene induction and
IFN-gamma induced CD54 regulation
McGillicuddy et al., J Biol Chem 2009
(Insulin Resistance) :
IFNgamma induced robust STAT1 phosphorylation and
SOCS1 mRNA expression, with modest, transient STAT3 phosphorylation and SOCS3 induction
Madonna et al., J Immunol 2010
(Psoriasis) :
The
IFN-gamma dependent
suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes ... In this study, we compared the expression levels of SOCS1 in keratinocytes isolated from skin affected by psoriasis with cells obtained from healthy donors, unveiling that keratinocytes are more prone than healthy cells to upregulate
SOCS1 mRNA expression in
response to
IFN-gamma
Hashimoto et al., Int Immunol 2011
(Hepatitis, Animal) :
SOCS1 regulates type I/type II NKT cell balance by regulating
IFNgamma signaling
Suzuki et al., Oncogene 1998
(Leukemia, Myeloid, Acute) :
In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while
JAB was
induced strongly by
IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)