Gene interactions and pathways from curated databases and text-mining

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IFNG — SOCS1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Park et al., Mol Endocrinol 2000 : IFN-gamma up-regulated SOCS-1 and SOCS-3 RNA and protein in FRTL-5 cells, as reported previously for nonthyroid cells
Sakamoto et al., Leukemia & lymphoma 2000 : Among them, we have shown that JAB/SOCS-1 is strongly induced by interferon-gamma and forced expression of JAB/SOCS-1I conferred cells interferon resistance
Saito et al., J Immunol 2000 : IFN regulatory factor-1 mediated transcriptional activation of mouse STAT induced STAT inhibitor-1 gene promoter by IFN-gamma ... Furthermore, forced expression of IRF-1 mimicked and that of IRF-2 inhibited the stimulatory effect of IFN-gamma on SSI-1 gene transcription ... These results demonstrated that IRF-1, which is induced by activation of Stat1, mediated transcriptional activation of the SSI-1 gene by IFN-gamma via VIRE
Metcalf et al., Proc Natl Acad Sci U S A 2000 (Myocarditis...) : Comparison of SOCS-1 -/- IFN-gamma +/- mice with various control mice indicated that the development of tissue damaging T lymphocyte, macrophage, and eosinophil infiltrates required loss of SOCS-1 and the presence of some IFN-gamma , but that the lung lymphoid infiltrates required only loss of SOCS-1 to develop
Cwikel et al., Exp Hematol 2001 : Interferon-gamma had no effect on CIS-3/JAB induction in these cells
Krebs et al., Stem Cells 2001 : The analysis of socs1 ( -/- ) mice has revealed that SOCS1 plays a key role in the negative regulation of interferon-gamma signaling and in T cell differentiation
Turnley et al., Neuroreport 2001 : SOCS1 expression by sensory neurons was up-regulated by IFNgamma
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : Suppressor of cytokine signaling (SOCS)1 and SOCS3 are negative regulators of IFN-gamma signaling and are induced in many cell types by IFN-gamma itself or by other cytokines ... We show in this work that SOCS1 , SOCS2, SOCS3, and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes, whereas only SOCS1 or SOCS1 and cytokine-inducible SH2 containing protein were induced by TNF-alpha or IL-4, respectively
Toniato et al., J Biol Chem 2002 : Functionally, expression of TRIM8/GERP decreases the repression of interferon-gamma signaling mediated by SOCS-1
Ding et al., J Immunol 2003 : IL-10 induced SOCS1 may directly inhibit IL-10 IFN-gamma signaling, while inhibition of other proinflammatory cytokine responses may use additional IL-10R1 mediated mechanisms
Cornish et al., J Biol Chem 2003 : SOCS-1-/-IFNgamma-/- mice also die before their wild type and IFNgamma-/- counterparts with a range of inflammatory conditions including pneumonia, gut infiltration, and skin ulceration, suggesting that SOCS-1 controls not only IFNgamma signaling, but also other immunoregulatory factors
Seifert et al., Exp Dermatol 2003 (Psoriasis) : Using real time RT-PCR we demonstrated that IL-10 is neither able to induce its typical early gene product suppressor of cytokine signalling (SOCS) 3 nor to modulate the interferone (IFN)-gamma induced expression of SOCS 1 and 3
Dalpke et al., Eur J Immunol 2003 : Overexpression of SOCS-1 and, to a lesser extend, of SOCS-3 and CIS inhibited IFN-gamma signaling as measured by activation of STAT1
Sato et al., Biochem Biophys Res Commun 2004 : IFN-gamma induced SOCS-1 regulates STAT6 dependent eotaxin production triggered by IL-4 and TNF-alpha ... We also demonstrated that SOCS-1 , a potent inhibitory molecule of IL-4 signaling, was induced by IFN-gamma in STAT1 dependent manner
Qing et al., J Biol Chem 2005 : Suppressor of cytokine signaling (SOCS)-1 , the key negative regulator of interferon (IFN)-gamma dependent signaling, is induced in response to IFNgamma ... SOCS-1 binds to and inhibits the IFNgamma receptor associated kinase Janus activated kinase (JAK) 2 and inhibits its function in vitro, but the mechanism by which SOCS-1 inhibits IFNgamma dependent signaling in vivo is not clear
Catlett et al., Nat Immunol 2005 : Suppressor of cytokine signaling 1 ( Socs1 ) is critical for the regulation of interferon-gamma responses and T cell homeostasis
Osna et al., Hepatology 2005 : In addition, SOCS1 , a negative regulator of IFNgamma signaling and which is degraded by the proteasome, was stabilized by ethanol treatment, presumably because of inhibited proteasome activity
Yao et al., J Virol 2005 : Silencing either SOCS1 or SOCS3 by small interfering RNA dramatically augments the production of IFN-gamma in T cells, thereby abrogating the inhibitory effect of core
Hwang et al., Int J Hematol 2006 : IFN-gamma up-regulated Socs1 messenger RNA expression in normal CD34+ cells, which was further enhanced with the addition of HGFs
Dickensheets et al., Genes Immun 2007 : Induction of SOCS-1 gene expression by IL-4 is STAT6 dependent, whereas induction of SOCS-1 by IFN-gamma is STAT1 dependent
Shoda et al., Biochem Biophys Res Commun 2007 (Pulmonary Fibrosis) : In contrast, IFN-gamma suppressed the increase of collagen production induced by IL-4 in wild type fibroblasts but not SOCS1-deficient fibroblasts, suggesting IFN-gamma acted exclusively via SOCS1 in this case
Waiboci et al., J Immunol 2007 : Both Tkip and SOCS1-KIR inhibited IFN-gamma activation of Raw 264.7 murine macrophages and inhibited Ag-specific splenocyte proliferation
Fojtova et al., Br J Cancer 2007 (Melanoma...) : The resistant subline ( termed WM 1158R ) differed from the sensitive subline ( WM 1158S ) by a constitutive expression of SOCS 3, lack or weak SOCS 1-3 activation following IFN-gamma , and short duration of cytokine activatory signal
Madonna et al., FASEB J 2008 : Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation ... Here we show that, after IFN-gamma stimulation, SOCS1 inhibited IFN-gamma receptor and STAT1 phosphorylation but maintained ERK1/2 activation
Takahashi et al., Cancer Sci 2008 : Taking into account the synergistic effect of pshSOCS-1 and IFN-gamma on the growth of B16-BL6 cells, these findings suggest that IFN-gamma induced high SOCS-1 gene expression in B16-BL6 cells significantly interferes with the antiproliferative effect of IFN-gamma
Koelsche et al., Mol Immunol 2009 : Altering the subcellular localization of SOCS1 by mutating clusters of arginine residues within the NLS did not affect the inhibition of interferon mediated STAT1 tyrosine-phosphorylation, but surprisingly led to impaired inhibitory activity of STAT mediated reporter gene induction and IFN-gamma induced CD54 regulation
McGillicuddy et al., J Biol Chem 2009 (Insulin Resistance) : IFNgamma induced robust STAT1 phosphorylation and SOCS1 mRNA expression, with modest, transient STAT3 phosphorylation and SOCS3 induction
Madonna et al., J Immunol 2010 (Psoriasis) : The IFN-gamma dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes ... In this study, we compared the expression levels of SOCS1 in keratinocytes isolated from skin affected by psoriasis with cells obtained from healthy donors, unveiling that keratinocytes are more prone than healthy cells to upregulate SOCS1 mRNA expression in response to IFN-gamma
Hashimoto et al., Int Immunol 2011 (Hepatitis, Animal) : SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)