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IL17D — IRF6
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Sonobe et al., Brain Res 2005
:
We show for the first time that murine microglia produce
IL-27 in
response to
lipopolysaccharide (LPS) and/or interferon-gamma
Kamakura et al., Biochem Biophys Res Commun 2006
:
Taken together,
LPS induced
activation of
IL-27p28 gene can be accounted for by the displacement of bound NonO protein from the IL-27p28 promoter
Xu et al., J Immunol 2007
(Encephalomyelitis, Autoimmune, Experimental) :
In primary astrocytes,
LPS induced the production of IL-12p40, IL-23, and
IL-27p28 proteins
Zhu et al., Scand J Immunol 2010
:
Stimulatory effect of
LPS and feedback
effect of PGE2 on
IL-27 production ... In this study, we investigated the
effect of
lipopolysaccharide (LPS) on the production of
IL-27 ... We found that
LPS stimulated
IL-27 production was in a dose dependent and time dependent manner in THP-1 cells ... The results suggest that PGE2 significantly inhibits
LPS induced
IL-27 production, without affecting basal IL-27 expression ... Further experiment suggests that PGE2 and
LPS regulate
IL-27 through NF-?B pathway
Gorina et al., Glia 2011
:
LPS induced early activation of the transcription factor NF?B, through the MyD88 adaptor, and expression of TNF-a, VCAM-1, IL-15, and
IL-27
Bosmann et al., J Immunol 2012
:
Genetic deficiency of either TLR4 or LBP completely incapacitated the ability of macrophages to secrete
IL-27 ( p28 ) in
response to
LPS
Benoit et al., J Immunol 2012
:
C1q bound to autologous apoptotic lymphocytes modulated expression of genes associated with JAK/STAT signaling, chemotaxis, immunoregulation, and NLRP3 inflammasome activation in LPS stimulated HMDMs. Specifically, C1q sequentially induced type I IFNs, IL-27, and IL-10 in
LPS stimulated HMDMs and
IL-27 in HMDMs when incubated with apoptotic lymphocyte conditioned media
Saito et al., Int Arch Allergy Immunol 2013
(Eosinophilic Granuloma...) :
In addition, the percentages of monocytes and the percentages of mDCs that produced
IL-27 and IL-23p19 in
response to
LPS stimulation were positively correlated with the percentages of Tr1 cells and Th17 cells in peripheral blood