UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to FAS

BIRC2 — FAS

Pathways - manually collected, often from reviews:

NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, inhibits)
Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) (modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction