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EPHB2 — PAK2

Text-mined interactions from Literome

Penzes et al., Neuron 2003 : Overexpression of dominant negative EphB receptor, catalytically inactive kalirin, or dominant negative Rac1, or inhibition of PAK eliminates ephrin induced spine development
Sundberg-Smith et al., J Biol Chem 2005 : Interestingly, deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene, indicating that association between PAK and ERK is required to facilitate ERK signaling
Stockton et al., Mol Biol Cell 2007 (Inflammation) : Erk in lipopolysaccharide (LPS) treated mouse lung is activated in a PAK dependent manner in several cell types, most prominently vascular endothelium
Suzuki et al., Cancer Res 2007 : Moreover, although the initial activation of Ras and PAK2 are distinctly regulated, TGF-beta stimulated PAK2 activity is required for Ras dependent ERK phosphorylation and Elk-1 transcription
Chow et al., PloS one 2010 (Cell Transformation, Neoplastic...) : However, in tumors, loss of Pak activity does not reduce Erk or Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
De la Mota-Peynado et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Erk3 protein is known to shuttle between the cytoplasm and the nucleus, and we showed that selective inhibition of class I Pak kinase activity in cells promoted increased nuclear accumulation of Erk3
Yablonski et al., EMBO J 1998 : TCR mediated activation of Erk2 was also inhibited by dominant negative Pak