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AGTR2 — BCL2
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Yang et al., Neurol Sci 2011
(Brain Ischemia...) :
Compared to saline treated control, NGF treatment
at 2 , 3 and 5 h after MCAO significantly reduced infarct volume, neural cell apoptosis and expression of caspase-3 ( P < 0.01 ),
up-regulated the expression of
Bcl-2 and improved functional recovery ( P < 0.01 )
Jiang et al., Molecular vision 2012
(Reperfusion Injury) :
The mRNA levels of Bcl-2 and
Bcl-XL significantly
increased at 2 , 4, and 6 h, peaked at 8 h, and decreased gradually, but remained at a higher level compared with the normal control, which was accompanied by an increase in NF-?B p65 in nuclear extracts
Horiuchi et al., J Biol Chem 1997
:
AT2 receptor activation did
affect intracellular
Bcl-2 protein levels