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CCR5 — IL4
Text-mined interactions from Literome
Athanassakis et al., Hum Immunol 2000
:
Furthermore, in the
presence of
IL-4 ,
CCR3 expression declines from 2 to 8 h of culture to increase again at 24 h, where 50 % of the cell population is expressing the receptors
Biasin et al., J Infect Dis 2000
:
However,
interleukin (IL)-6 , IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ;
CCR5 and CXCR4 mRNA were
augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Wang et al., J Infect Dis 2002
(HIV Infections) :
IL-4 stimulated HIV-1 replication in MDMs but
down-regulated CD4 and
CCR5 expression and inhibited virus entry, whereas IL-10 had the opposite effects
Pedroza-Martins et al., J Virol 2002
(HIV Infections) :
IL-2 and
IL-4 together
increased expression of CXCR4 and
CCR5 in this population, whereas IL-4 and IL-7 increased CXCR4 but not CCR5 expression
Bosco et al., Cell Immunol 2004
:
CCR5 upregulation by IL-10, LPS, and
IL-4 was also antagonized by hypoxia
Zhang et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid) :
In contrast,
interleukin-12 stimulation
induced the up-regulation of
CCR5 and a shift in the in vivo homing pattern away from the lymph nodes toward the inflamed synovium
Creery et al., Viral Immunol 2006
:
Differential
regulation of CXCR4 and
CCR5 expression by
interleukin (IL)-4 and IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus ( HIV ) type 1 replication but not HIV entry into human monocytes ... In this study, we investigated the
effects of
IL-4 and IL-13 on the expression of CXCR4 and
CCR5 , and the biological implications of alteration of CXCR4 and CCR5 regulation on monocytic cells with respect to their migration in response to chemokines, HIV entry, and its replication
Jiang et al., Chin Med J (Engl) 2009
(Embryo Loss) :
Expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model, selectively
induced by
IL-4 and IL-10, regulates the embryo resorption rate ... Expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model, selectively
induced by
IL-4 and IL-10, regulates the embryo resorption rate ... This study aimed to observe whether
IL-4 and IL-10 may
regulate the expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model and to explore the role of CCR3, CCR5, CXCR3 in immune tolerance in pregnancy ... This study aimed to observe whether
IL-4 and IL-10 may
regulate the expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model and to explore the role of CCR3, CCR5, CXCR3 in immune tolerance in pregnancy ... The pregnancy immune tolerance may be
induced through selective induction of CCR3,
CCR5 and CXCR3 expressions by
IL-4 together with IL-10
Wang et al., Thorax 2013
(Asthma...) :
However,
CCR8 inhibition
had no significant effect on allergen induced BAL eosinophilia and the induction of the Th2 cytokines
IL-4 , IL-5, IL-13 and mucus levels in BAL
Valentin et al., Proc Natl Acad Sci U S A 1998
(Disease Progression) :
IL-4 also activates HIV-1 expression in primary monocytes/macrophages but does not
affect CCR5 expression
Wang et al., J Virol 1998
:
In contrast, addition of the T-helper 2 ( Th2 ) cell derived cytokine interleukin-4 (IL-4) or IL-13 prevented the expression of
CCR5 induced by culture in medium alone, and
IL-4 inhibited virus entry, replication, and cytopathicity under these conditions ...
IL-4 or IL-13 also
prevented the stimulatory effects of M-CSF or GM-CSF on
CCR5 expression as well as HIV-1 entry and replication