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IL4 — ITGA4

Text-mined interactions from Literome

Suwaki et al., Int Immunopharmacol 2001 (Asthma...) : PAF or IL-4 did not enhance VLA-4 expression on eosinophils, and there was no significant effect of suplatast on VLA-4 expression in allergic patients
Sasaki et al., J Immunol 2008 (Neoplasms) : Our recent studies have suggested that VLA-4 expression on CD8+ T cells is negatively controlled by IL-4 and serves as a functionally distinguishing variable for why Type-1, but not Type-2, CD8+ T cells are able to traffic into tumors ... In this study, using in vitro culture of murine CD8+ T cells under Type-1 and Type-2 cytokine conditions, we show that IL-4 mediated down-regulation of VLA-4 expression is completely abrogated in Stat6-deficient CD8+ T cells
Sasaki et al., Eur J Immunol 2008 (Melanoma, Experimental) : IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit ... Notably, the inhibitory effects of IL-4 on Tc1 expression of VLA-4 could be blocked by the presence of IL-12, but not IFN-gamma
Paganin et al., Cytokine 1994 : The levels of inhibition with resting vs IL-1 activated EC, as well as antibody blocking experiments, suggested that IL-4 exerts an inhibitory influence predominantly on the beta 2-integrin ( CD18 ) -dependent adhesion pathway ; nevertheless IL-4 did not affect the expression of CD18/CD11a and VLA-4 on the NK cell surface, as assessed by flow cytometry