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BMP2 — SPP1

Text-mined interactions from Literome

Yang et al., J Biol Chem 2000 : Previously, we have reported that Smad1 activates osteopontin gene expression in response to bone morphogenetic protein simulation through an interaction with a homeodomain transcription factor, Hoxc-8
Hullinger et al., Exp Cell Res 2001 : These results strongly suggest that both the Hox- and the Smad binding regions play a role in BMP-2 induced activation of the OPN promoter
Liu et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2000 : [ Effect of recombinant human bone morphogenetic protein-2 on the expression of osteopontin in human periodontal ligament cells ]
Huang et al., Bone 2004 : Overexpression of OPN inhibited BMP-2 responsiveness while overexpression of antisense RNA enhanced the effect of BMP-2 on alkaline phosphatase activity ... Furthermore, endogenous OPN expression in response to BMP-2 exhibited a biphasic pattern, that is, it was initially inhibited and then enhanced by the treatment of BMP-2, indicating that OPN might function as a negative feedback regulator for osteoblastic differentiation
Osyczka et al., Endocrinology 2005 : Either treating human MSC cultures with the MAPK/ERK kinase inhibitor PD98059 or transferring them to serum-free medium with insulin or IGF-I permits BMP dependent increases in the expression of the early osteoblast associated genes, alkaline phosphatase and osteopontin ... In contrast, inhibiting the insulin/IGF-I activated PI3-K/AKT pathway decreases BMP induced alkaline phosphatase and osteopontin expression in serum-free cultures of human MSC, but increases BMP activation of Smads ; thus, PI3-K signaling is required for BMP induced expression of early osteoblast genes in human MSC either downstream or independent of the BMP activated Smad signaling pathway
Shen et al., Exp Cell Res 2007 : Antisense targeting of TGF-beta1 augments BMP induced upregulation of osteopontin , type I collagen and Cbfa1 in human Saos-2 cells
Muthukuru et al., J Periodontol 2013 : Results : BMP2 was a potent inducer of osteocalcin/osteopontin ( statistically significant at P < 0.01 ) and osteonectin in PDL cells relative to stimulation with doxycycline
Zhou et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 : Adenovirus mediated overexpression of BMP-2 and BMP-3, however, promoted osteogenesis of NP cells and significantly increased the expression of osteocalcin mRNA ; the overexpression of BMP-2 , but not BMP-3, enhanced the mRNA expressions of osteoprotegerin and osteopontin