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Givant-Horwitz et al., Gynecol Oncol 2004
(MAP Kinase Signaling System...) :
The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010
:
Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Auger-Messier et al., Circ Res 2013
(Cardiomyopathies...) :
Although single nulls showed no molecular effects, combined disruption of Dusp1/4 promoted unrestrained p38 MAPK activity in both mouse embryonic fibroblasts and the heart, with no change in the phosphorylation of c-Jun N-terminal kinases or extracellular signal regulated kinases at baseline or with stress stimulation