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Liang et al., Endocrinology 1999
:
GH induces activation of the GH receptor (GHR) associated cytoplasmic tyrosine kinase, JAK2, resulting in tyrosine phosphorylation of the GHR and activation of STAT ( signal transducer and activator of transcription ), Ras-mitogen activated protein kinase , and phosphoinositol 3-kinase signaling pathways, among others
Winston et al., J Biol Chem 1995
:
Employing the transient expression of dominant negative forms of H-Ras and Raf-1, we determined that the GHR/JAK2 mediated activation of ERK2/MAPK is dependent on both Ras and Raf