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MYLIP — PTGS2

Text-mined interactions from Literome

Tanaka et al., Differentiation 2009 : Indeed, Cox-2 protein expression was suppressed by the overexpression of miR-101a, and the luciferase activity of reporter constructs containing the Cox-2 3'UTR was also suppressed by miR-101a overexpression
Gao et al., Cancer 2010 (Adenocarcinoma...) : Overexpression of miR-218 also inhibited NF-kappaB transcriptional activation and transcription of cyclooxygenase -2 , a proliferative gene regulated by NF-kappaB
Ji et al., FEBS Lett 2010 : Overexpression of miR-26b marginally reduces the levels of COX-2 protein in DFOM treated CNE cells
Hao et al., Cancer prevention research (Philadelphia, Pa.) 2011 (Prostatic Neoplasms) : In this study, we investigated the mechanism of microRNA-101 (miR-101) regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2 associated cancer ... We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region ( 3'-UTR ) of COX-2 mRNA
Liu et al., FEBS Lett 2011 : Overexpression of miR-98 inhibited TLR4 triggered IL-10 production and promoted COX-2 expression
Kim et al., PloS one 2011 : Luciferase assay and transfection confirmed miR-143 binding to 3 ' UTR of prostaglandin-endoperoxidase synthase 2 ( PTGS2 ) mRNA and miR-143 regulation of PTGS2 in AMCs
Young et al., Mol Cancer Res 2012 (Carcinoma...) : In colorectal cancer cells and tumors, miR-16 levels were decreased approximately twofold and miR-16 expression in cancer cells attenuated COX-2 expression and PG synthesis
Akhtar et al., Ann Rheum Dis 2012 (Osteoarthritis) : miR-199a* directly suppressed the luciferase activity of a COX-2 3'UTR reporter construct and inhibited the IL-1ß induced expression of COX-2 protein in OA chondrocytes ... Treatment with antimiR-101_3 increased COX-2 expression in IL-1ß stimulated chondrocytes, but overexpression of miR-101_3 had no significant effect on COX-2 protein expression
Liu et al., J Gastroenterol 2013 (Helicobacter Infections...) : Overexpression of miR-146a resulted in significantly reduced PTGS2 production induced by H. pylori infection
Kumar et al., Cell Microbiol 2012 : In addition, M.tb. induced miR-155 inhibits expression of cyclooxygenase-2 (Cox-2) and interleukin-6 (Il-6), two modulators of the innate immune response
He et al., FEBS J 2012 (Adenocarcinoma...) : One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA
Iyer et al., PloS one 2012 (Brain Diseases...) : In addition, the expression of IL-6 and COX-2 upon IL-1ß stimulation was suppressed by increased levels of miR-146a and increased by the reduction of miR-146a
Kothapalli et al., Atherosclerosis 2013 : Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2 dependent repression of miR221/222
Li et al., Cancer cell international 2013 : Overexpression of miR-26b led to downregulation of PTGS2 at the mRNA and protein level, as assessed by qRT-PCR and Western blot
Park et al., Osteoarthritis Cartilage 2013 (Osteoarthritis, Knee) : To investigate the repressive effect of miR-558 on COX-2 expression, human chondrocytes and chondrogenic SW1353 cells were transfected with mature miR-558 or an antisense inhibitor ( anti-miR-558 ) ... The overexpression of miR-558 directly suppressed the luciferase activity of a reporter construct containing the 3'-UTR of human COX-2 mRNA and significantly inhibited IL-1ß induced upregulation of COX-2 , while treatment with anti-miR-558 enhanced IL-1ß induced COX-2 expression and reporter activity in chondrocytes