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IL10 — IL5

Text-mined interactions from Literome

Elliott et al., Int J Tuberc Lung Dis 1999 (HIV Infections...) : In association with HIV infection, IFN-gamma responses to mycobacterial antigens were profoundly impaired ( odds ratio [ OR ] 0.10 for PPD, 0.06 for CFP, P < or =0.001 ), but production of IL-2, IL-5 and TNF-alpha was relatively sustained, and IL-10 increased or sustained ( OR 3.97 for PPD, P = 0.01, 1.14 for CFP, P = 0.99 )
Qiu et al., Zhongguo Yao Li Xue Bao 1999 : Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages
Pacocha et al., J Interferon Cytokine Res 2000 : Finally, whereas IFN-beta inhibited antigen-driven generation of IL-5 , IL-12, IL-13, and IFN-gamma, IFN-beta enhanced generation of both IL-4 and IL-10
Staples et al., Biochem Biophys Res Commun 2000 : By contrast, IL-10 totally inhibited CD3 + CD28 induced IL-5 release and inhibited mRNA by 50-60 %
Suchin et al., J Am Acad Dermatol 2001 (Eosinophilia...) : Increased interleukin 5 production in eosinophilic Sézary syndrome : regulation by interferon alfa and interleukin 12
Kelly et al., Reproduction 2001 : Prostaglandins have major effects on cytokine production but the direct action of prostaglandin E on leucocytes is not a pro-inflammatory response but is to stimulate interleukin 10 and inhibit interleukin 12 synthesis
Grunstein et al., Am J Physiol Lung Cell Mol Physiol 2001 (Asthma...) : Moreover, extended studies demonstrated that 1 ) exogenous IL-10 administration to naive ASM elicited augmented contractility to acetylcholine and impaired relaxation to isoproterenol, 2 ) these effects of IL-10 were prevented by pretreating the tissues with an IL-5 receptor Ab, and 3 ) IL-10 administration induced upregulated mRNA expression and release of IL-5 protein from cultured ASM cells
Byrnes et al., Ann Neurol 2002 (Multiple Sclerosis, Chronic Progressive...) : Interleukin-10 , a dominant endogenous inhibitor of interleukin-12 , is largely protective in these experimental surrogates for multiple sclerosis
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Uchimura et al., Clin Exp Immunol 2002 (Graves Disease) : The effects of CD40- and interleukin ( IL-4 ) -activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves ' disease : the role of CD8+ cells
Luo et al., Hunan Yi Ke Da Xue Xue Bao 2000 (Asthma) : CONCLUSION : IL-5 and EOS might play a role in the pathogenesis of asthma, the inhibition of IL-10 mRNA expression may cause the increase of IL-5 expression in asthma ... The beneficial effects of corticosteroid treatment in asthma may partly result from increasing IL-10 mRNA expression and inhibiting IL-5 mRNA expression
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Chiang et al., Am J Respir Crit Care Med 2003 (Asthma...) : The data showed that ribavirin and ODN 1826 increased interleukin-12 synthesis and inhibited interleukin-10 production
Jani et al., Plant Cell Rep 2004 : Macrophages isolated from mice immunised with native or plant expressed CTB showed enhanced secretion of interleukin-10 but secretion of lipopolysaccharide induced interleukin-12 and tumor necrosis factor alpha was inhibited
Weir et al., Infect Immun 2004 (Tuberculosis) : Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom ... To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives ( PPDs )
Zhou et al., Mol Cell Biol 2004 : Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway
Peçanha et al., J Immunol 1992 : IL-10 inhibits IL-5- but not IL-2 induced Ig secretion by T cell independent antigens
Araújo et al., Mem Inst Oswaldo Cruz 2004 (Asthma...) : Patients with asthma and helminth infections produced less IL-5 than patients with asthma without helminth infections, and this down regulation could, in part, be mediated by IL-10
Romano et al., Clin Immunol 2005 (Acute Disease...) : The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects
Peek et al., Am J Respir Cell Mol Biol 2005 (Dermatitis, Atopic) : Allergen-specific T cell lines induced in the presence of salmeterol and fluticasone proprionate inhibited IL-5 and IL-13 production by allergen-specific Th2 cell lines in an IL-10 dependent manner
Obonyo et al., FEMS Immunol Med Microbiol 2006 (Helicobacter Infections) : Evidence for interleukin-1 independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori infected murine dendritic cells deficient in the interleukin-1 receptor
Gogishvili et al., Int Arch Allergy Immunol 2007 (Asthma...) : This was associated with decreased IL-4 and IL-5 levels, and increased IL-10 levels in BAL fluids as well as increased amounts of IL-10 producing CD25+ regulatory T cells
Forsythe et al., Am J Respir Crit Care Med 2007 (Asthma...) : Oral treatment with live Lactobacillus reuteri but not Lactobacillus salivarius significantly attenuated the influx of eosinophils to the airway lumen and parenchyma and reduced the levels of tumor necrosis factor, monocyte chemoattractant protein-1, IL-5 , and IL-13 in bronchoalveolar lavage fluid of antigen challenged animals, but there was no change in eotaxin or IL-10
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Yin et al., J Toxicol Environ Health 2007 (Listeriosis) : DEP or eDEP concentration-dependently suppressed L. monocytogenes induced secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-12 by AM and of IL-2 and interferon-gamma by lymphocytes obtained from L. monocytogenes infected rats, but augmented the AM secretion of IL-10
Mutapi et al., BMC infectious diseases 2007 (Schistosomiasis haematobia) : Furthermore people producing high levels of IL-10 produced little or no IL-5, suggesting that IL-10 may be involved in the regulation of IL-5 levels
Bellinghausen et al., Clin Exp Allergy 2008 (Hypersensitivity) : While in non sensitized donors IL-4 and IL-5 as well as IL-10 production were also increased after stimulation with monomeric HL-Per a 3-pulsed DC, Th2 cytokine and IL-10 production were only enhanced in P. americana sensitized donors using hexameric HL-Per a 3-pulsed DC
Buisson et al., J Infect Dis 2009 (HIV Infections) : These functional changes may be at least partly explained by reduced interleukin-12 and increased interleukin-10 secretion on stimulation with lipopolysaccharide and CD40 ligand
Elliott et al., Vaccine 2010 (HIV Infections...) : Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon ( IFN-? ), IL-5 and IL-13 responses ; other maternal helminth infections showed little effect
Ding et al., ACS Appl Mater Interfaces 2011 : The inhibition of inducible nitric oxide synthase and interleukin-1 expression and the activation of interleukin-10 were increased with increasing gelatin content
Uchiyama et al., Journal of cardiothoracic surgery 2012 : Proliferation of splenocytes, interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and IL-10 from opera exposed transplant recipients increased compared to that from splenocytes of untreated recipients
Daniłowicz-Luebert et al., Int J Parasitol 2013 (Hypersensitivity) : Ex vivo restimulation with cystatin of spleen cells from cystatin treated mice induced the production of IL-10 , while cystatin inhibited allergen-specific IL-5 and IL-13 levels
Chung et al., J Infect Dis 2013 (Leprosy, Lepromatous...) : Galectin-3 enhanced monocyte interleukin 10 production to a TLR2/1 ligand, whereas interleukin 12p40 secretion was unaffected
Haben et al., Eur J Immunol 2013 (Disease Models, Animal...) : Litomosoides sigmodontis-specific IFN-?, IL-5 , and IL-13 production increased in the absence of T-cell derived IL-10 at early and late time points of infection
Thompson et al., J Neurotrauma 2013 (Spinal Cord Injuries) : The best characterized effects of IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß), interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9, nitric oxide synthase, myeloperoxidase, and reactive oxygen species
Lin et al., Int J Pediatr Otorhinolaryngol 2013 : Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well controlled children ( p < 0.05 )
Swain et al., Proc Natl Acad Sci U S A 1981 : We conclude that the C.C3.11.75 TRF activity is not due to interleukin 1 or to interleukin 2 but to a third factor provisionally designated as ( DL ) TRF
de Waal Malefyt et al., J Immunol 1993 : The production and mRNA levels of IL-4, IL-5 , IFN-gamma, and granulocyte/macrophage-CSF were not affected by IL-10
Warren et al., J Immunol 1995 : Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10 , and IL-12 ... IL-5 secretion, particularly in primary cultures, is augmented by IL-4 and is inhibited by IL-12 and IL-10
Zaitseva et al., Infect Immun 1995 : Gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-5 induction was assayed by mRNA-specific PCR and by enzyme linked immunosorbent assay and bioassay for protein production
Finkelman et al., J Exp Med 1994 (Intestinal Diseases, Parasitic...) : IL-12 stimulated IFN-gamma and IL-10 gene expression during primary and secondary N. brasiliensis infections and inhibited IL-3, IL-4, IL-5 , and IL-9 gene expression during primary infections but had little inhibitory effect during secondary infections
Steel et al., J Infect Dis 1994 (Onchocerciasis) : Before treatment, Onchocerca volvulus antigen ( OvA ) elicited interleukin (IL)-5 production but inhibited production of IL-10 , granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha
Del Prete et al., J Immunol 1993 : h-IL-10 and v-IL-10 also inhibited the Ag-induced production of gamma-interferon ( IFN-gamma ) by Th1 clones and the production of IL-4 and IL-5 by Th2 clones, whereas they had no effect on the cytokine synthesis by the same clones stimulated with PMA plus anti-CD3 antibody
Tilg et al., Cytokine 1995 (Neoplasms) : Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy
Benveniste et al., Proc Natl Acad Sci U S A 1996 (Acute Disease...) : Comparative interleukin ( IL-2 ) /interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Venkataraman et al., Cryobiology 1996 : X. Decrease in interleukin-12 production by frozen human peripheral blood mononuclear cells is mediated by the endogenously hypersecreted interleukin-10
Boros et al., Immunology 1998 (Granuloma) : Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis mansoni infected mice
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10 , transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Pai et al., Oncol Res 1998 : Differential effect of interleukin 10 on interleukin 12- and interleukin 2-mediated killer induction from blood mononuclear cells