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CASP9 — CDC6
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Bellosillo et al., Blood 2001
(Lymphoproliferative Disorders) :
In addition, no cells with a hypodiploid DNA content were detected and
R-CDC was not
prevented by a broad-spectrum
caspase inhibitor, suggesting a caspase independent mechanism
Yim et al., Mol Biol Cell 2003
:
Thus, the
caspase mediated cleavage of
Cdc6 creates a truncated Cdc6 fragment that is retained in the nucleus and induces apoptosis
Li et al., Anticancer Drugs 2006
:
In conclusion, our study reveals that NCTD can inhibit DNA replication, and induce apoptosis and
caspase-3 dependent cleavage of
Cdc6
Yim et al., J Cell Biol 2006
:
Cdc6-UM expression
attenuates the TNF-alpha induced activation of ATM and
caspase-3 activities
Xiong et al., Mutat Res 2009
(Carcinoma, Hepatocellular...) :
Interestingly, the G1321A polymorphism did not affect
caspase mediated cleavage of
Cdc6 during etoposide induced apoptosis, but it was predicted to alter the secondary structure of Cdc6 mRNA