Oshima et al., Circulation 2008
(Reperfusion Injury) :
Using an inducible Akt1 transgenic mouse model, we have found that follistatin-like 1 (Fstl1) protein and transcript expression are increased 4.0- and 2.0-fold, respectively, by Akt activation in the heart ( P < 0.05 )
Winbanks et al., J Cell Biol 2012
(Hypertrophy) :
Expression of constitutively active Smad3 not only markedly prevented skeletal muscle growth induced by follistatin but also potently suppressed follistatin induced Akt/mTOR/S6K signaling