Gene interactions and pathways from curated databases and text-mining

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CD8A — IL5

Text-mined interactions from Literome

Braun et al., Eur J Immunol 2000 : In mixed lymphocyte cultures ( MLC ), the presence of CD8 ( + ) T cells in the responding cell population inhibited the secretion of IL-5
Lee et al., J Interferon Cytokine Res 2000 (Mast-Cell Sarcoma) : Dose dependent and schedule dependent effects of interleukin-12 on antigen-specific CD8 responses
Soldan et al., J Immunol 2003 (Multiple Sclerosis, Chronic Progressive...) : The increase in IL-5 was primarily due to an increase in CD4 ( + ) and CD8 ( + ) T cells, the increase in IL-10 was primarily due to an increase in CD64 ( + ) monocytes/macrophages with some effect in T cells, while the decrease in TNF-alpha was primarily due to a decrease in CD8 ( + ) T cells
Cao et al., Cell Mol Immunol 2004 (Carcinoma...) : Global gene expression profiling in interleukin-12 induced activation of CD8 ( + ) cytotoxic T lymphocytes against mouse mammary Carcinoma
Willemsen et al., J Immunol 2006 (Melanoma) : The introduction of a mutated cysteine motif in CD8alpha, which prevents its binding to LCK and linker for activation of T cells, did not adversely affect expression and T cell cytotoxicity, but counteracted the CD8alpha mediated down-regulation of IL-4 and IL-5 , but not IL-10
Wells et al., J Allergy Clin Immunol 2007 (Inflammation...) : Adoptive transfer of transgenic antigen-specific CD8 , but not CD4, cells resulted in increased IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Ohnishi et al., J Allergy Clin Immunol 2009 (Inflammation...) : Adoptive transfer of U0126 treated CD8 ( + ) T cells into sensitized mice before secondary allergen challenge resulted in significant decreases in AHR, eosinophilic inflammation, goblet cell metaplasia, and IL-5 and IL-13 levels in bronchoalveolar lavage fluid of recipient mice
Ma et al., Scand J Immunol 2011 (Colonic Neoplasms) : This study aims to investigate the role of tumour derived Foxhead box P3 (Foxp3) ( + ) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific CD8 ( + ) T cells
Höllsberg et al., Proc Natl Acad Sci U S A 1995 : CD8 T-cell stimulation with the wild-type peptide antigen led to activation of p56lck kinase activity, interleukin 2 secretion, cytotoxicity, and clonal expansion