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ESR1 — NOS1
Text-mined interactions from Literome
Scordalakes et al., J Comp Neurol 2002
:
We asked whether
estrogen receptor-alpha (ERalpha) and/or androgen receptor (AR)
regulated nNOS immunoreactivity in mouse brain
Simoncini et al., Arterioscler Thromb Vasc Biol 2003
:
By interacting with phosphatidylinositol 3-kinase (PI3K),
estrogen receptor (ER) alpha
leads to activation of protein kinase Akt and to subsequent increase in endothelial
nitric oxide synthase activity
Xia et al., Endocrinology 2004
(Neuroblastoma) :
These results demonstrate that E2-stimulated NO production occurs via
estrogen receptor mediated activation of the constitutive NOSs,
neuronal NOS and eNOS
Gingerich et al., Endocrinology 2005
:
We used the selective ERalpha agonist, propyl-pyrazole-triol ( 10 nm ), and antagonist, methyl-piperidino-pyrazole ( 1 microm ), to exclude the possibility that
ERalpha is
involved in the E2-induced increase in eNOS and
nNOS in the PVN
Kumar et al., Mol Endocrinol 2007
:
In endothelial cells, the disruption of
ER alpha-G alpha i interaction
prevents estradiol induced
nitric oxide synthase activation and the resulting attenuation of monocyte adhesion that contributes to estrogen related cardiovascular protection
Cignarella et al., J Pharmacol Exp Ther 2009
(Diabetes Mellitus, Experimental...) :
Distinct
roles of
estrogen receptor-alpha and beta in the modulation of vascular inducible
nitric-oxide synthase in diabetes