Gene interactions and pathways from curated databases and text-mining

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ESR1 — NOS1

Text-mined interactions from Literome

Scordalakes et al., J Comp Neurol 2002 : We asked whether estrogen receptor-alpha (ERalpha) and/or androgen receptor (AR) regulated nNOS immunoreactivity in mouse brain
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Xia et al., Endocrinology 2004 (Neuroblastoma) : These results demonstrate that E2-stimulated NO production occurs via estrogen receptor mediated activation of the constitutive NOSs, neuronal NOS and eNOS
Gingerich et al., Endocrinology 2005 : We used the selective ERalpha agonist, propyl-pyrazole-triol ( 10 nm ), and antagonist, methyl-piperidino-pyrazole ( 1 microm ), to exclude the possibility that ERalpha is involved in the E2-induced increase in eNOS and nNOS in the PVN
Kumar et al., Mol Endocrinol 2007 : In endothelial cells, the disruption of ER alpha-G alpha i interaction prevents estradiol induced nitric oxide synthase activation and the resulting attenuation of monocyte adhesion that contributes to estrogen related cardiovascular protection
Cignarella et al., J Pharmacol Exp Ther 2009 (Diabetes Mellitus, Experimental...) : Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes