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ANXA6 — EGF
Text-mined interactions from Literome
Dixon et al., Hepatology 1999
:
Culture of hepatocytes with TGF-beta for 16 hours decreased the
stimulation by
EGF of ERK2 and
p70 ( S6k ) ( by 50 % and 35 %, respectively ), but did not affect the stimulation of either p38 MAPK, c-jun NH2-terminal kinase ( JNK ), or protein kinase B (PKB) ... Culture of hepatocytes with glucagon for 16 hours also inhibited the
stimulation by
EGF of activation of ERK2 and
p70 ( S6k ) ( by approximately 50 % )
Majidi et al., J Biol Chem 2000
:
Furthermore, expression of
p70 in COS-7 cells suppresses activation of mitogen activated protein kinase MAPK/ERK2 by the largest ST5 product, p126, in
response to
epidermal growth factor stimulation
Yan et al., J Cell Physiol 2000
:
Although we found that
EGF stimulated
p70s6K phosphorylates through a MAPK dependent and a MAPK independent ( wortmannin-sensitive ) pathway, TGF-beta1 failed to block EGF triggered phosphorylation of p70s6K at thr ( 389 ) and thr ( 421 ) /ser ( 424 ) sites, implying that PKB inhibition by TGF-beta1 may result from inhibition of PDK1 activity instead of inhibition of PI3K activity
Law et al., J Biol Chem 2000
:
Interestingly, low salicylate concentrations ( < /=250 microm ) inhibit p70 ( s6k ) activation by phorbol myristate acetate, while higher salicylate concentrations ( > /=5 mm ) are required to block
p70 ( s6k )
activation by
epidermal growth factor + insulin-like growth factor-1
Nomura et al., Mol Carcinog 2003
(Cell Transformation, Neoplastic) :
Treatment with rapamycin inhibited
EGF induced phosphorylation and activation of ribosomal
p70 S6 protein kinase (p70 S6K) , an mTOR downstream target, but had no effect on phosphorylation and activation of Akt ... The expression of DNM-Akt1 also suppressed
EGF induced
p70 S6K
activation as well as Akt activation
Qiu et al., Mol Hum Reprod 2004
:
In this study,
EGF significantly
stimulated HTR8/SVneo cell migration and the phosphorylation of AKT, ERK1/2 and
p70S6K in a concentration dependent manner ... The MAPK inhibitor U0126 decreased cell migration and ERK phosphorylation, but it did not influence
p70S6K phosphorylation in
response to
EGF
Chwieralski et al., Am J Respir Cell Mol Biol 2004
:
EGF induced phosphorylation of extracellular signal regulated kinases ( ERK ) 1/2, c-Jun-N-terminal kinase, p38, Akt, and
p70S6K in BEAS-2B cells
Susa et al., J Biol Chem 1992
:
Inhibition or down-regulation of protein kinase C attenuates late phase
p70s6k activation
induced by
epidermal growth factor but not by platelet derived growth factor or insulin ... The late phase of the time dependent
epidermal growth factor (EGF) induced biphasic activation of the
p70s6k is selectively attenuated by the specific PKC inhibitor, CGP 41,251, a staurosporine derivative
Grewal et al., Oncogene 2005
:
Since we have demonstrated that
annexin A6 inhibits
EGF- and TPA induced Ras signalling, we investigated whether modulation of Ras activity by annexin A6 was mediated via altered subcellular localization of p120GAP
Nomura et al., Mol Carcinog 2005
(Cell Transformation, Neoplastic) :
Interestingly, pretreatment with caffeine suppressed
EGF induced phosphorylation and activation of Akt and ribosomal
p 70 S6 protein kinase (p 70 S 6 K) , a target of Akt, without inhibiting phosphatidylinositol 3-kinase (PI 3 K) activation
Billington et al., Biochemistry 2005
:
These data suggest that PI3K dependent T389/T229 phosphorylation is limiting in late-phase
p70S6K activation by
EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell growth
Galbaugh et al., BMC cell biology 2006
:
While expression of CA-Akt caused a constitutive activation of p70S6 kinase (p70S6K) in HC11 cells, the inhibition of either PI-3-kinase or mTOR abolished the
activation of
p70S6K by
EGF ... The
activation of
p70S6K by insulin or
EGF resulted in the phosphorylation of ribosomal protein S6 (RPS6), elongation initiation factor 4E ( elF4E ) and 4E binding protein1 (4E-BP1) ... However,
p70S6K phosphorylation persisted in the
presence of lactogenic hormone and
EGF , but the activation could be blocked by a PI-3-kinase inhibitor
Liu et al., Free Radic Biol Med 2006
(Neovascularization, Pathologic) :
The inhibition of H ( 2 ) O ( 2 ) production by catalase abolished
EGF induced AKT and
p70S6K1 activation, and VEGF expression through HIF-1alpha expression
Krymskaya et al., Am J Physiol 1997
:
Interestingly, TGF-beta 1 did not modulate
EGF induced
p70 S6 kinase activity, which is important for the progression of cells from the G0 to the G1 phase of the cell cycle
Peak et al., Diabetologia 1998
:
Both insulin and
EGF activated extracellular regulated kinase 2 (ERK-2),
p70rsk and protein kinase B (PKB) and inactivated glycogen synthase kinase-3 ( GSK-3 )
Majidi et al., J Biol Chem 1998
:
In vivo, expression of p126, but not p82 or
p70 , activated MAPK/ERK2 in
response to
EGF in COS-7 cells