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CREBBP — HDAC1

Pathways - manually collected, often from reviews:

• BioCarta wnt signaling pathway: HDAC (HDAC1) → CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) (modification, activates)
  
• BioCarta multi-step regulation of transcription by pitx2: Pitx2/HDAC complex (PITX2-HDAC1) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
  
• BioCarta multi-step regulation of transcription by pitx2: Pitx2/HDAC complex (PITX2-HDAC1) → p300/CBP/Pitx2 complex (CREBBP-EP300-PITX2) (modification, collaborate)
  
• BioCarta multi-step regulation of transcription by pitx2: HDAC (HDAC1) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
  
• BioCarta multi-step regulation of transcription by pitx2: HDAC (HDAC1) → p300/CBP/Pitx2 complex (CREBBP-EP300-PITX2) (modification, collaborate)
  
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1) (modification, inhibits)
  Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: TGIF/SIN3/HDAC complex/CtBP complex (TGIF1-CTBP1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1) (modification, inhibits)
  Wotton et al., Cell 1999, Yahata et al., J Biol Chem 2000, Melhuish et al., J Biol Chem 2000, Wotton et al., Cell Growth Differ 2001, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1) (modification, inhibits)
  Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC1 — CREBBP (physical association, affinity chromatography technology) Mayanil et al., J Biol Chem 2006*
• IRef Biogrid Interaction: HDAC1 — CREBBP (physical association, affinity chromatography technology) Chuang et al., Nucleic Acids Res 2006*
• IRef Hprd Interaction: HDAC1 — CREBBP (in vivo) Chuang et al., Nucleic Acids Res 2006*
• IRef Intact Interaction: Complex of EP300-ATF3-RELA-CREBBP-HDAC1 (association, anti bait coimmunoprecipitation) Hua et al., J Biol Chem 2006*

Text-mined interactions from Literome

Suzuki et al., Int J Cancer 2000 (Mouth Neoplasms...) : TSA enhanced the protein expression of p21 ( WAF1 ), CREB binding protein , cyclinE, cyclin A, Bak and Bax, while it reduced the expression of E2F-1, E2F-4, HDAC1 , p53 and hyperphosphorylated form of Rb
Vo et al., Mol Cell Biol 2001 : In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself