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HRAS — PARP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PARP1 → HRAS (decreases, HRAS Translocation)
  Evidence: Detection of PARP cleavage (Figure 4a) and analysing the amount of subG1 cells (Figure 2c) demonstrated that this U0126-mediated block of the MEK/ERK/RSK cascade triggered a significant loss of the potential of Ras to mediate cell survival over tuberin-induced apoptosis.
• OpenBEL Selventa BEL large corpus: PARP1 → HRAS (decreases, HRAS Translocation)
  Evidence: W estern blot analyses revealed that cleavage of both, PARP and caspase 3, is downregulated by RasV12 under these experimental conditions (Figure 1d).

Text-mined interactions from Literome

Ichiba et al., FEBS Lett 1999 : We demonstrated that GFR can activate Rap1 but not H-Ras in 293T cells and that the cdc25 domain of GFR is required for the activation of Rap1
Beaudry et al., Endocrinology 2006 : Treatment of cells with Gö6976 was also found to inhibit p21(ras) ( between 1-10 min ) but stimulated Rap1 activity ( 1-5 min ) in a time-course similar to that of Ang II