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NGF — PI3
Text-mined interactions from Literome
Kelly et al., Neuropharmacology 2000
:
The evidence presented is consistent with the hypothesis that
PI 3-kinase activation , possibly by
NGF , plays a role in expression of LTP in dentate gyrus
Bilderback et al., J Neurochem 2001
:
Intriguingly,
NGF induced an association of activated
PI 3-kinase with acid sphingomyelinase (SMase) ...
NGF stimulated
PI 3-kinase activity was necessary for inhibition of acid SMase but was not required for ligand induced association of the p85 subunit of PI 3-kinase with the phospholipase
Kimpinski et al., J Neurosci Res 2001
(MAP Kinase Signaling System) :
Activation of
PI 3-kinase and SNT by both
NGF and IGF-1 correlated with their effects on neurite growth
Kronfeld et al., Eur J Immunol 2002
:
The results of this study indicate that
NGF is involved in B cell survival and that this effect is
mediated by
PI3-kinase dependent activation of PKCzeta
Ohmichi et al., Neuron 1992
:
NGF causes the rapid stimulation of
PI-3 kinase activity detected in anti-phosphotyrosine, but not in anti-trk, immunoprecipitates
Wang et al., Neurotox Res 2001
:
These effects of
NGF required activation of both
PI 3-kinase and MAP kinase signal pathways
Wu et al., Cell Signal 2005
:
Here, we investigated the possible involvement of G ( i/o ) proteins in
nerve growth factor (NGF) induced pro-survival
phosphatidylinositol-3-kinase (PI3K)/Akt signaling in rat pheochromocytoma PC12 cells
Itakura et al., J Neurochem 2005
:
These results indicate that PI3-kinase participates in the enhancement of neurotransmitter release by two distinct mechanisms : EGF and
NGF activate
PI3-kinase in the plasma membrane, whereas IGF-1 activates PI3-kinase possibly in the intracellular membrane, leading to enhancement of neurotransmitter release in a MAPK dependent and -independent manner respectively
Park et al., Mol Cells 2006
:
The p38 mitogen activated protein kinase ( MAPK ) inhibitor, SB203580,
phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C ( PKC ) inhibitor, chelerythrine,
had no effect on activation of promoter IV by
NGF
Park et al., J Biol Chem 2007
:
Specifically,
NGF enhanced TrkA phosphorylation,
PI3K activity, and Akt phosphorylation
Ohmichi et al., Biochemistry 1993
:
AG879 also inhibited
NGF induced PLC-gamma 1 phosphorylation,
phosphatidylinositol-3 (PI3) kinase
activation , the association of the tyrosine phosphorylated proteins pp100 and pp110 with the p85 subunit of PI-3 kinase, mitogen activated protein and raf-1 kinases, and c-fos induction
Spear et al., Arch Biochem Biophys 1998
:
Activation of
PI 3-kinase by
NGF pretreatment completely protected against both the enhanced apoptosis induced by FGF-1 pretreatment and NGF posttreatment and the apoptosis induced by peroxynitrite alone