Dulos et al., Arthritis Rheum 2004
(Arthritis, Experimental...) :
In addition, the regulatory role of IL-1beta on CYP7B activity in FLS was determined using RT-PCR, Western blotting, and high-performance liquid chromatography ... In addition, IL-1beta enhanced CYP7B mRNA and CYP7B protein levels in FLS
Jahan et al., Am J Physiol Gastrointest Liver Physiol 2005
(MAP Kinase Signaling System) :
Real-time PCR assays revealed that both chenodeoxycholic acid ( CDCA ) and interleukin-1beta (IL-1beta) markedly reduced CYP8B1, cholesterol 7alpha-hydroxylase CYP7A1 and hepatic nuclear factor 4alpha ( HNF4alpha ) mRNA expression levels in human primary hepatocytes
Li et al., Hepatology 2006
:
IL-1 beta and CDCA reduced CYP7A1 but induced c-Jun messenger RNA expression in human primary hepatocytes ... IL-1beta inhibited human CYP7A1 reporter activity via the HNF4 alpha binding site