Hashimoto et al., Environ Mol Mutagen 2002
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Trp-P-1 activated the serine-threonine protein kinase Akt , which is known to be an anti-apoptotic protein, and increased the DNA binding activities of apoptosis associated transcription factors NF-kappaB and AP-1
Kedlaya et al., Arch Biochem Biophys 2011
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Inhibition of AKT phosphorylation using a PI3-kinase inhibitor abolishes this interaction and results in retardation TRP1 in the Golgi