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FOXM1 — FOXO3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
McGovern et al., Mol Cancer Ther 2009
(Breast Neoplasms...) :
We also showed that ectopic expression of an active
FOXO3a represses
FOXM1 expression, whereas knockdown of FOXO3a expression using small interfering RNA can up-regulate FOXM1 and its downstream targets polo-like kinase, cyclin B1, and CDC25B and rescue sensitive BT474 cells from gefitinib induced cell proliferative arrest
Sengupta et al., Circ Res 2013
:
In vivo, combined loss of FoxO1 and
FoxO3 specifically in cardiomyocytes
leads to delayed cell-cycle withdrawal and increased expression of IGF1 and
FoxM1
Yung et al., BMC cancer 2013
(Uterine Cervical Neoplasms) :
Interestingly, activated AMPK could not cause any significant changes in FOXM1 in cervical cancer cells in which endogenous FOXO3a levels were knocked down using siRNAs, suggesting that
FOXO3a is
involved in the suppression of
FOXM1